Alcohol abuse and alcohol dependence are key factors in the development of alcohol use
disorder, which is a pervasive societal problem with substantial economic, medical, and …

Rationale Over the last decade, oxycodone has become one of the most widely abused drugs
in the USA. Oxycodone use disorder (OUD) is a serious health problem that has prompted …

A large focus of modern neuroscience has revolved around preselected brain regions of
interest based on prior studies. While there are reasons to focus on brain regions implicated in …

Substance use disorders have a complex etiology. Genetics, the environment, and behavior
all play a role in the initiation, escalation, and relapse of drug use. Recently, opioid use …

Autism spectrum disorder (ASD) affects ~2% of the population in the US, and monogenic
forms of ASD often result in the most severe manifestation of the disorder. Recently, SCN2A …

Background Alcohol binge drinking in humans is thought to increase the risk for alcohol use
disorder (AUD). Unclear is whether drinking patterns (eg, bingelike or stable drinking) …

Background In humans, emotional and physical signs of withdrawal from ethanol are commonly
seen. Many of these symptoms, including anxiety‐like and depression‐like behavior, …

GPR139 is an orphan G protein-coupled receptor (GPCR) that is expressed mainly in the
brain, with the highest expression in the medial habenula. The modulation of GPR139 receptor …

The rat oxycodone and cocaine biobanks contain samples that vary by genotypes (by using
genetically diverse genotyped HS rats), phenotypes (by measuring addiction-like behaviors …

Bioelectricity is defined as endogenous electrical signaling mediated by the dynamic
distribution of charged molecules. Recently, increasing evidence has revealed that cellular …