A substantial fraction of the proteome is intrinsically disordered, and even well-folded
proteins adopt non-native geometries during synthesis, folding, transport, and turnover. …

The dimensions that unfolded proteins, including intrinsically disordered proteins (IDPs), adopt
in the absence of denaturant remain controversial. We developed an analysis procedure …

To import large metabolites across the outer membrane of gram-negative bacteria, TonB-dependent
transporters (TBDTs) undergo significant conformational change. After substrate …

Hydrogen‐deuterium exchange mass spectrometry (HDX‐MS) is a powerful tool that monitors
protein dynamics in solution. However, the reversible nature of HDX labels has largely …

Chromatin-binding proteins play vital roles in the assembly and recruitment of multi-subunit
complexes harboring effector proteins to specific genomic loci. MRG15, a chromodomain-…

The origins of the discrepancy between SAXS and FRET measurements of IDP dimensions
remain controversial. To address this, we recently developed a robust analysis for extracting …

468a Wednesday, February 23, 2022 lumen of the transmembrane b-barrel, must rearrange
to form a pore and permit passage of the substrate, which is initially bound at the TBDT’s …

During metabolite transport, TonB dependent receptors, found in the outer membranes of
many bacterial species, are hypothesized to unfold their N-terminal “plug” domain. The 130 aa …

To import large metabolites across the outer membrane (OM) of Gram-negative bacteria,
TonB dependent transporters (TBDTs) undergo significant conformational change. After …

Methods: A cohort of 66 PVV patients with the first symptoms of the disease at the age of 15-40
years (the median age of 25 (IQR 20-32) years) was selected for this study. Exome …