The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for
mucosal immune responses in the initiation or perpetuation of the systemic autoimmunity that …

Although studies have identified the presence of gut-associated cells in the enthesis of joints
affected by spondylarthritis (SpA), a direct link through cellular transit between the gut and …

Cell fusion occurs in development and in physiology and rarely in those settings is it associated
with malignancy. However, deliberate fusion of cells and possibly untoward fusion of …

Despite expression of immunogenic polypeptides, tumors escape immune surveillance by
engaging T cell checkpoint regulators and expanding Tregs, among other mechanisms. What …

Host genes define the severity of inflammation and immunity but specific loci doing so are
unknown. Here we show that TNF receptor superfamily member 13B (TNFRSF13B) variants, …

Background Axial spondyloarthritis (axSpA) has strong connections with intestinal
inflammation as occurs in Crohn’s disease (CD). However, the immunologic mechanisms that …

TNFRSF13B encodes the transmembrane activator and CAML interactor (TACI) receptor,
which drives plasma cell differentiation. Although TNFRSF13B supports host defense, …

Intraepithelial lymphocytes (IELs) are T cells important for the maintenance of barrier integrity
in the intestine. Colon IELs are significantly reduced in both MyD88-deficient mice and …

The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for mucosal
immune responses in the initiation and/or perpetuation of the systemic autoimmunity that …

TNFRSF13B encodes the “transmembrane-activator and CAML-interactor” (TACI) receptor,
which drives plasma cell differentiation. Although TNFRSF13B supports host defense, …