Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion
AR Leman, C Noguchi, CY Lee… - Journal of cell …, 2010 - journals.biologists.com
The Timeless-Tipin protein complex has been reported to be important for replication
checkpoint and normal DNA replication processes. However, the precise mechanisms by which …
checkpoint and normal DNA replication processes. However, the precise mechanisms by which …
[HTML][HTML] The replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplication
AR Leman, E Noguchi - Genes, 2013 - mdpi.com
Eukaryotic cells must accurately and efficiently duplicate their genomes during each round
of the cell cycle. Multiple linear chromosomes, an abundance of regulatory elements, and …
of the cell cycle. Multiple linear chromosomes, an abundance of regulatory elements, and …
Local and global functions of Timeless and Tipin in replication fork protection
AR Leman, E Noguchi - Cell cycle, 2012 - Taylor & Francis
The eukaryotic cell replicates its chromosomal DNA with almost absolute fidelity in the course
of every cell cycle. This accomplishment is remarkable considering that the conditions for …
of every cell cycle. This accomplishment is remarkable considering that the conditions for …
An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum
…, B Cummins, KE Roche, CM Kelliher, AR Leman… - Science, 2020 - science.org
The blood stage of the infection of the malaria parasite Plasmodium falciparum exhibits a 48-hour
developmental cycle that culminates in the synchronous release of parasites from red …
developmental cycle that culminates in the synchronous release of parasites from red …
Timeless preserves telomere length by promoting efficient DNA replication through human telomeres
AR Leman, J Dheekollu, Z Deng, SW Lee, MM Das… - Cell cycle, 2012 - Taylor & Francis
A variety of telomere protection programs are utilized to preserve telomere structure.
However, the complex nature of telomere maintenance remains elusive. The Timeless protein …
However, the complex nature of telomere maintenance remains elusive. The Timeless protein …
Warm nights disrupt transcriptome rhythms in field-grown rice panicles
…, LMF Lawas, AM Valente, AR Leman… - Proceedings of the …, 2021 - National Acad Sciences
In rice, a small increase in nighttime temperature reduces grain yield and quality. How warm
nighttime temperatures (WNT) produce these detrimental effects is not well understood, …
nighttime temperatures (WNT) produce these detrimental effects is not well understood, …
[HTML][HTML] Investigating Conservation of the Cell-Cycle-Regulated Transcriptional Program in the Fungal Pathogen, Cryptococcus neoformans
CM Kelliher, AR Leman, CS Sierra, SB Haase - PLoS genetics, 2016 - journals.plos.org
The pathogenic yeast Cryptococcus neoformans causes fungal meningitis in immune-compromised
patients. Cell proliferation in the budding yeast form is required for C. neoformans to …
patients. Cell proliferation in the budding yeast form is required for C. neoformans to …
[HTML][HTML] The Local Edge Machine: inference of dynamic models of gene regulation
KA McGoff, X Guo, A Deckard, CM Kelliher, AR Leman… - Genome biology, 2016 - Springer
We present a novel approach, the Local Edge Machine, for the inference of regulatory
interactions directly from time-series gene expression data. We demonstrate its performance, …
interactions directly from time-series gene expression data. We demonstrate its performance, …
The Double-Bromodomain Proteins Bdf1 and Bdf2 Modulate Chromatin Structure to Regulate S-Phase Stress Response in Schizosaccharomyces pombe
…, MA Ziegler, MM Das, T Singh, LJ Harper, AR Leman… - Genetics, 2012 - academic.oup.com
Bromodomain proteins bind acetylated histones to regulate transcription. Emerging evidence
suggests that histone acetylation plays an important role in DNA replication and repair, …
suggests that histone acetylation plays an important role in DNA replication and repair, …
A normalization method that controls for total RNA abundance affects the identification of differentially expressed genes, revealing bias toward morning‐expressed …
…, A Vennapusa, IM Somayanda, AR Leman… - The Plant …, 2024 - Wiley Online Library
RNA‐Sequencing is widely used to investigate changes in gene expression at the
transcription level in plants. Most plant RNA‐Seq analysis pipelines base the normalization …
transcription level in plants. Most plant RNA‐Seq analysis pipelines base the normalization …