It is becoming increasingly apparent that heat shock proteins play an important role in the
survival of Plasmodium falciparum against temperature changes associated with its passage …

Heat shock proteins (Hsps) are conserved molecules whose main role is to facilitate folding
of other proteins. Most Hsps are generally stress-inducible as they play a particularly …

Heat shock proteins act as molecular chaperones, facilitating protein folding in cells of living
organisms. Their role is particularly important in parasites because environmental changes …

Obligate protozoan parasites of the kinetoplastids and apicomplexa infect human cells to
complete their life cycles. Some of the members of these groups of parasites develop in at least …

Certain kinetoplastid (Leishmania spp. and Trypanosoma cruzi) and apicomplexan parasites
(Plasmodium falciparum and Toxoplasma gondii) are capable of invading human cells as …

Malaria remains the world's most devastating tropical infectious disease with as many as 40%
of the world population living in risk areas. The widespread resistance of Plasmodium …

Malaria is caused by Plasmodium species, whose transmission to vertebrate hosts is facilitated
by mosquito vectors. The transition from the cold blooded mosquito vector to the host …

Presently, artemisinin-based combination therapy (ACT) is the first-line therapy of Plasmodium
falciparum malaria. With the emergence of malaria parasites that are resistant to ACT, …

Heat shock protein 70 (Hsp70) and heat shock protein 40 (Hsp40) are molecular chaperones
that ensure that the proteins of the cell are properly folded and functional under both …

Heat shock protein 70 (Hsp70) and heat shock protein 40 (Hsp40) function as molecular
chaperones during the folding and trafficking of proteins within most cell types. However, the …