Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives
many of the cancer "hallmarks" through downstream activation of the gp130/STAT3 signaling …

Gastrointestinal cancers are frequently associated with chronic inflammation and excessive
secretion of IL-6 family cytokines, which promote tumorigenesis through persistent activation …

Anti-microbial signaling pathways are normally triggered by innate immune receptors when
detecting pathogenic microbes to provide protective immunity. Here we show that the …

Polymorphisms in NFKB1 that diminish its expression have been linked to human inflammatory
diseases and increased risk for epithelial cancers. The underlying mechanisms are …

Inflammasomes are key regulators of innate immunity in chronic inflammatory disorders and
autoimmune diseases, but their role in inflammation-associated tumorigenesis remains ill-…

Colorectal cancer is treated with antibodies blocking epidermal growth factor receptor (EGF-R),
but therapeutic success is limited. EGF-R is stimulated by soluble ligands, which are …

Aberrant activation of the SRC family kinase hematopoietic cell kinase (HCK) triggers
hematological malignancies as a tumor cell-intrinsic oncogene. Here we find that high HCK levels …

Simple Summary Colorectal cancer is the second leading cause of cancer-related death
worldwide. The immune system plays a key role in controlling tumour onset and development. …

ADP-ribosylation is an important posttranslational protein modification that regulates diverse
biological processes, controlled by dedicated transferases and hydrolases. Here, we show …

Chronic inflammation of the large intestine is associated with an increased risk of developing
colorectal cancer (CRC), the second most common cause of cancer-related deaths …