The functional relationship between apoptosis ('self-killing') and autophagy ('self-eating') is
complex in the sense that, under certain circumstances, autophagy constitutes a stress …

Autophagy is characterized by sequestration of bulk cytoplasm and organelles in double or
multimembrane autophagic vesicles, and their delivery to and subsequent degradation by …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical, …

Research in autophagy continues to accelerate, 1 and as a result many new scientists are
entering the field. Accordingly, it is important to establish a standard set of criteria for …

WILD-TYPE p53 protein has many properties consistent with its being the product of a
tumour suppressor gene 1–3 . Although the normal roles of tumour suppressor genes are still …

Cell death is essential for a plethora of physiological processes, and its deregulation
characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its …

Programmed cell death is often triggered by the interaction of some cytokines with their cell
surface receptors. Here, we report that gamma interferon (IFN-gamma) induced in HeLa cells …

Autophagy, an evolutionarily conserved process, has functions both in cytoprotective and
programmed cell death mechanisms. Beclin 1, an essential autophagic protein, was recently …

Death-associated protein kinase (DAPk) and DAPk-related protein kinase (DRP)-1 proteins
are Ca +2 /calmodulin–regulated Ser/Thr death kinases whose precise roles in programmed …

Autophagy is a physiological and evolutionarily conserved phenomenon maintaining
homeostatic functions like protein degradation and organelle turnover. It is rapidly upregulated …