The tendency of 5-methylcytosine (5mC) to undergo spontaneous deamination has had a
major role in shaping the human genome, and this methylation damage remains the primary …

… Adil SA Al Hinai, Adil SA Al Hinai … Associations between variables were tested by the Fisher’s
exact test for categorical variables and by the Mann-Whitney U test for continuous variables…

… Adil SA Al Hinai … Getta et al. investigated if NGS could be used for MRD detection, in this
study defined as mutations present above a VAF of 5% before HSCT. Mutations detected by a …

Background Patients with acute myeloid leukemia (AML) often reach complete remission, but
relapse rates remain high. Next-generation sequencing enables the detection of molecular …

Cytosine methylation is essential for normal mammalian development, yet also provides a
major mutagenic stimulus. Methylcytosine (5mC) is prone to spontaneous deamination, which …

Acute myeloid leukemia (AML) patients with partial tandem duplications (PTDs) in the Mixed
Lineage Leukemia (MLL) officially known as the Lysine (K)-specific Methyltransferase 2A (…

Kinase hyperactivity is a common driver of acute myeloid leukemia (AML) and serves as a
therapeutic target. 1 The most frequent activating genetic aberrations in AML are internal …

Recurrent somatic internal tandem duplications (ITD) in the FMS‐like tyrosine kinase 3 (FLT3)
gene characterise approximately one third of patients with acute myeloid leukaemia (AML)…

Overexpression of the BRE (brain and reproductive organ-expressed) gene defines a distinct
pediatric and adult acute myeloid leukemia (AML) subgroup. Here we identify a promoter …

… Adil SA Al Hinai … Adil SA Al Hinai … Publisher’s note Springer Nature remains neutral
with regard to jurisdictional claims in published maps and institutional affiliations. …