Background Recent studies demonstrated that the triple combination cystic fibrosis transmembrane
conductance regulator (CFTR) modulator therapy elexacaftor/tezacaftor/ivacaftor (ETI…

Background Mucin disulfide cross-links mediate pathologic mucus formation in muco-obstructive
lung diseases. MUC-031, a novel thiol-modified carbohydrate compound, cleaves …

The nasal epithelium represents the first line of defense against inhaled pathogens, allergens,
and irritants and plays a key role in the pathogenesis of a spectrum of acute and chronic …

Background We recently demonstrated that the triple combination CFTR modulator therapy
elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) improves lung ventilation and airway mucus …

Adenine nucleotides represent crucial immunomodulators in the extracellular environment.
The ectonucleotidases CD39 and CD73 are responsible for the sequential catabolism of ATP …

Crohns disease (CD) is an inflammatory bowel disease (IBD) that can affect any part of the
gastrointestinal tract, frequently involving the terminal ileum. While colonic mucus alterations …

Increased disulfide crosslinking of secreted mucins causes elevated viscoelasticity of mucus
and is a key determinant of mucus dysfunction in patients with cystic fibrosis (CF) and other …

The initial phase of fracture healing decides on success of bone regeneration and is
characterized by an inflammatory milieu and low oxygen tension (hypoxia). Negative interference …

Primary ciliary dyskinesia (PCD) is a congenital disease leading to an impairment of the
mucociliary clearance.Culturing primary human epithelial cells (phNEC) at air-liquid-interface (…

Background: Adenosine and its nucleotides represent crucial immunomodulators in the
extracellular environment. ATP and ADP are released from stressed cells in states of …