O-glycosylation is one of the most abundant and diverse types of post-translational modifications
of proteins. O-glycans modulate the structure, stability, and function of proteins and …

Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …

We present a method to enrich for glycoproteins from proteomic samples. Sialylated
glycoproteins were selectively periodate-oxidized, captured on hydrazide beads, trypsinized and …

Background Global analyses of proteins and their modifications by mass spectrometry are
essential tools in cell biology and biomedical research. Analyses of glycoproteins represent …

Production of glycoprotein therapeutics in Chinese hamster ovary (CHO) cells is limited by
the cells' generic capacity for N-glycosylation, and production of glycoproteins with desirable …

The proteolytic processing of human amyloid precursor protein (APP) into shorter aggregating
amyloid β (Aβ)-peptides, eg, Aβ1-42, is considered a critical step in the pathogenesis of …

Self-avoidance, a process preventing interactions of axons and dendrites from the same
neuron during development, is mediated in vertebrates through the stochastic single-neuron …

Urine is a complex mixture of proteins and waste products and a challenging biological fluid
for biomarker discovery. Previous proteomic studies have identified more than 2800 urinary …

The metazoan O-mannose (O-Man) glycoproteome is largely unknown. It has been shown
that up to 30% of brain O-glycans are of the O-Man type, but essentially only alpha-…

Mucins are a large family of heavily O-glycosylated proteins that cover all mucosal surfaces
and constitute the major macromolecules in most body fluids. Mucins are primarily defined …