Lysine-targeted inhibitors and chemoproteomic probes
A Cuesta, J Taunton - Annual Review of Biochemistry, 2019 - annualreviews.org
Covalent inhibitors are widely used in drug discovery and chemical biology. Although
covalent inhibitors are frequently designed to react with noncatalytic cysteines, many ligand …
covalent inhibitors are frequently designed to react with noncatalytic cysteines, many ligand …
Ligand conformational bias drives enantioselective modification of a surface-exposed lysine on Hsp90
A Cuesta, X Wan, AL Burlingame… - Journal of the American …, 2020 - ACS Publications
Targeted covalent modification of surface-exposed lysines is challenging due to their low
intrinsic reactivity and high prevalence throughout the proteome. Strategies for optimizing the …
intrinsic reactivity and high prevalence throughout the proteome. Strategies for optimizing the …
Discovery of lysine-targeted eIF4E inhibitors through covalent docking
Eukaryotic translation initiation factor 4E (eIF4E) binds the m7GTP cap structure at the 5′-end
of mRNAs, stimulating the translation of proteins implicated in cancer cell growth and …
of mRNAs, stimulating the translation of proteins implicated in cancer cell growth and …
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity
CD4 + T helper lymphocytes that express interleukin-17 (T H 17 cells) have critical roles in
mouse models of autoimmunity, and there is mounting evidence that they also influence …
mouse models of autoimmunity, and there is mounting evidence that they also influence …
Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells
…, RS Longman, JX Zhang, B Breart, C Galan, A Cuesta… - Nature, 2013 - nature.com
The intestinal microbiota has a critical role in immune system and metabolic homeostasis,
but it must be tolerated by the host to avoid inflammatory responses that can damage the …
but it must be tolerated by the host to avoid inflammatory responses that can damage the …
Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes
Advances in chemoproteomic technology have revealed covalent interactions between small
molecules and protein nucleophiles, primarily cysteine, on a proteome-wide scale. Most …
molecules and protein nucleophiles, primarily cysteine, on a proteome-wide scale. Most …
Reversible lysine-targeted probes reveal residence time-based kinase selectivity
The expansion of the target landscape of covalent inhibitors requires the engagement of
nucleophiles beyond cysteine. Although the conserved catalytic lysine in protein kinases is an …
nucleophiles beyond cysteine. Although the conserved catalytic lysine in protein kinases is an …
Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting
…, L Deming, SD Axen, E Caceres, W Chen, A Cuesta… - Elife, 2016 - elifesciences.org
10.7554/eLife.15802.001 Ubiquitin is essential for eukaryotic life and varies in only 3 amino
acid positions between yeast and humans. However, recent deep sequencing studies …
acid positions between yeast and humans. However, recent deep sequencing studies …
Gas phase decomposition of t-butyl methyl ether catalyzed by different hydrogen halides: A dft study
… GAS PHASE DECOMPOSITION OF T-BUTYL METHYL ETHER CATALYZED BY
DIFFERENT HYDROGEN HALIDES: A DFT STUDY Cuesta et al., 65–79 … GAS PHASE …
DIFFERENT HYDROGEN HALIDES: A DFT STUDY Cuesta et al., 65–79 … GAS PHASE …
Diseño de una red IMS para la ciudad de Ica
CF Cabrejos Escajadillo, EA Cuesta Alvear - 2009 - tesis.pucp.edu.pe
El primer capítulo muestra el estado del arte de la tecnología IMS (IP Multimedia Subsystem),
es decir, su estandarización, la evolución de su arquitectura y algunas aplicaciones o …
es decir, su estandarización, la evolución de su arquitectura y algunas aplicaciones o …