The p38 MAPK pathway is well known for its role in transducing stress signals from the
environment. Many key players and regulatory mechanisms of this signaling cascade have been …

Post-transcriptional methylation of N6-adenine and N1-adenine can affect transcriptome
turnover and translation. Furthermore, the regulatory function of N6-methyladenine (m 6 A) …

Protein biogenesis is tightly linked to protein quality control (PQC). The role of PQC
machinery in recognizing faulty polypeptides is becoming increasingly understood. Molecular …

Tumor cells adapt their metabolism to meet the energetic and anabolic requirements of high
proliferation and invasiveness. The metabolic addiction has motivated the development of …

Stress-activated protein kinases (SAPKs) enhance survival in response to environmental
changes. In yeast, the Hog1 SAPK and Mrc1, a protein required for DNA replication, define a …

10.7554/eLife.29388.001 Cells respond to protein misfolding and aggregation in the cytosol
by adjusting gene transcription and a number of post-transcriptional processes. In parallel to …

At any stage of their lifecycle, mRNAs are coated by specialized proteins. One of few
circumstances when free mRNA appears in the cytosol is the disassembly of polysomes during the …

Post-transcriptional modifications of nucleotide bases can effect several aspects of mRNA
function. For example, the recent work has established the role of m 6 A in the coordinated …

Transient sequestration of proteins and RNA is an essential principle of cellular reaction to
stress. Compared to polypeptides, less is known about the role of RNA released from …

Protein quality control (PQC) machinery is in charge of ensuring protein homeostasis in the
cell, ie proteostasis. Chaperones assist polypeptides throughout their maturation until …