Cancer cells can develop a strong addiction to discrete molecular regulators, which control
the aberrant gene expression programs that drive and maintain the cancer phenotype. Here, …

A main clinical parameter of COVID-19 pathophysiology is hypoxia. Here we show that hypoxia
decreases the attachment of the receptor-binding domain (RBD) and the S1 subunit (S1) …

Factor-inhibiting HIF (FIH) is an asparagine hydroxylase that acts on hypoxia-inducible factors
(HIFs) to control cellular adaptation to hypoxia. FIH is expressed in several tumor types, …

Schwann cells are the main glial cells of the peripheral nervous system (PNS) and play key
roles in peripheral nerve development and function, including providing myelin that is …

Autophagy is a key cellular mechanism involved in the degradation of long-lived proteins and
organelles. We and others have previously shown that Schwann cells are able to degrade …

Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive sarcomas with a
strong metastatic potential, usually to the lung (1). MPNST patients are largely refractory to …

A main clinical parameter of Covid-19 pathophysiology is hypoxia. Here we show that hypoxia
decreases the attachment of the receptor binding domain (RBD) and the S1 subunit (S1) …

Myelination of axons is essential for the rapid saltatory conduction of action potentials. The
ensheathment of axons is carried by specialized glial cells, oligodendrocytes in the central …

Since its appearance, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2),
the causal agent of Coronavirus Disease 2019 (COVID-19), represents a global problem for …

Myelination is essential for neuronal function and health. In peripheral nerves, >100 causative
mutations have been identified that cause Charcot-Marie-Tooth disease, a disorder that …