User profiles for Adrián Varela-Vázquez
 | Adrián Varela-VázquezUniversidade da Coruña, INIBIC Verified email at udc.es Cited by 90 |
[HTML][HTML] Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
…, A Guitián-Caamaño, A Varela-Vázquez… - Cell death & …, 2022 - nature.com
The accumulation of senescent cells is a key characteristic of aging, leading to the progression
of age-related diseases such as osteoarthritis (OA). Previous data from our laboratory …
of age-related diseases such as osteoarthritis (OA). Previous data from our laboratory …
[HTML][HTML] Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis
M Varela-Eirín, A Varela-Vázquez… - Cell death & …, 2018 - nature.com
Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a
leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo …
leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo …
[HTML][HTML] Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in …
…, A Sánchez-Temprano, A Varela-Vázquez… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Articular cartilage and synovial tissue from patients with osteoarthritis (OA) show an overactivity
of connexin43 (Cx43) and accumulation of senescent cells associated with disrupted …
of connexin43 (Cx43) and accumulation of senescent cells associated with disrupted …
[HTML][HTML] Recruitment of RNA molecules by connexin RNA-binding motifs: Implication in RNA and DNA transport through microvesicles and exosomes
M Varela-Eirin, A Varela-Vazquez, MRC Mateos… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Connexins (Cxs) are integral membrane proteins that form high-conductance plasma membrane
channels, allowing communication from cell to cell (via gap junctions) and from cells to …
channels, allowing communication from cell to cell (via gap junctions) and from cells to …
[HTML][HTML] Emerging functions and clinical prospects of connexins and pannexins in melanoma
A Varela-Vázquez, A Guitián-Caamaño… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Cellular communication through gap junctions and hemichannels formed by connexins and
through channels made by pannexins allows for metabolic cooperation and control of …
through channels made by pannexins allows for metabolic cooperation and control of …
[HTML][HTML] The C-terminal domain of connexin43 modulates cartilage structure via chondrocyte phenotypic changes
…, JF Bechberger, M Varela-Eirin, A Varela-Vazquez… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Chondrocytes in cartilage and bone cells population express connexin43 (Cx43) and gap
junction intercellular communication (GJIC) is essential to synchronize cells for coordinated …
junction intercellular communication (GJIC) is essential to synchronize cells for coordinated …
FRI0529 spread of senescence and joint inflammation via connexin43-positive exosomes released by osteoarthritic chondrocytes
M Varela-Eirín, A Varela-Vázquez, A Guitián-Caamaño… - 2019 - ard.bmj.com
Background Chondrocytes (CHs) in articular cartilage undergo phenotypic changes and
senescence, restricting cartilage regeneration and favoring osteoarthritis (OA) progression. CHs …
senescence, restricting cartilage regeneration and favoring osteoarthritis (OA) progression. CHs …
Expression of connexin 43 in the human hair follicle: emphasis on the connexin 43 protein levels in the bulge and through the keratinization process
AF Flores, A Varela‐Vazquez… - Journal of …, 2018 - Wiley Online Library
Background Gap junctions form communication compartments between cells. These channels
assemble from connexin subunits. Objective To investigate the immunoexpression of …
assemble from connexin subunits. Objective To investigate the immunoexpression of …
Connexin 43 expression in cutaneous biopsies of lupus erythematosus
A Fernandez-Flores, A Varela-Vazquez… - The American Journal …, 2022 - journals.lww.com
Results: In 19 cases (67.86%), staining of more than half of the dermal vessels including
both vessels of the papillary and of the reticular dermis was identified. Only in 4 cases (14.28%), …
both vessels of the papillary and of the reticular dermis was identified. Only in 4 cases (14.28%), …
Connexin 43 in Dermatofibroma and Dermatofibrosarcoma Protuberans: Diagnostic, Pathogenic, and Therapeutic Implications
A Fernandez-Flores, A Varela-Vazquez… - The American Journal …, 2023 - journals.lww.com
Connexins play a crucial role in the formation of gap junctions that connect cells to each
other, as well as cells to the surrounding environment. In recent years, connexin 43 has been …
other, as well as cells to the surrounding environment. In recent years, connexin 43 has been …