A novel molecular class that recruits HDAC/MECP2 complexes to PU. 1 motifs reduces neuroinflammation

…, B Czako, Y Lightfoot, WJ Ray, A Beckmann… - Journal of Experimental …, 2023 - rupress.org
Pervasive neuroinflammation occurs in many neurodegenerative diseases, including Alzheimer’s
disease (AD). SPI1/PU.1 is a transcription factor located at a genome-wide significant …

[HTML][HTML] Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system

P Ramirez, G Zuniga, W Sun, A Beckmann… - Progress in …, 2022 - Elsevier
Transposable elements comprise almost half of the mammalian genome. A growing body of
evidence suggests that transposable element dysregulation accompanies brain aging and …

[PDF][PDF] Pathogenic tau causes a toxic depletion of nuclear calcium

…, EO Thomas, P Ramirez, HE Miller, A Beckmann… - Cell reports, 2020 - cell.com
Synaptic activity-induced calcium (Ca 2+ ) influx and subsequent propagation into the
nucleus is a major way in which synapses communicate with the nucleus to regulate …

[PDF][PDF] Moesin is an effector of tau-induced actin overstabilization, cell cycle activation, and neurotoxicity in Alzheimer's disease

A Beckmann, P Ramirez, M Gamez, E Gonzalez… - Iscience, 2023 - cell.com
In Alzheimer's disease, neurons acquire phenotypes that are also present in various cancers,
including aberrant activation of the cell cycle. Unlike cancer, cell cycle activation in post-…

Pathogenic tau disrupts the cellular program that maintains neuronal identity

A Beckmann, P Ramirez, M Gamez, WJ Ray, B Frost - BioRxiv, 2021 - biorxiv.org
Neurons in human Alzheimer’s disease acquire phenotypes that are also present in various
cancers, including over-stabilization of the cytoskeleton, nuclear pleomorphism, …

Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium Mediated by BK Channels

…, P Ramirez, H Miller, A Beckmann… - … Beckmann, Adrian …, 2020 - papers.ssrn.com
Synaptic activity-induced calcium ion (Ca 2+) influx and subsequent propagation of Ca 2+
into the nucleus is a major way in which synapses communicate with the nucleus to regulate …

Nuclear spin relaxation in methane gas

PA Beckmann - 1975 - open.library.ubc.ca
Nuclear spin relaxation in low density methane gas (CH₄) is investigated both experimentally
and theoretically. The 30 MHz nuclear magnetic resonance experiments were performed …

Pathogenic Tau Drives Neuronal Death by Mimicking Epithelial to Mesenchymal Transition in Neurons

A Beckmann - 2021 - search.proquest.com
Neurons in human Alzheimer’s disease acquire phenotypes that are also present in various
cancers, including over-stabilization of the cytoskeleton, nuclear pleomorphism, …

PATHOLOGICAL TAU ABORTS CELL CYCLE ACTIVATION BY MIMICKING EPITHELIAL-MESENCHYMAL-TRANSITION IN NEURONS

RV Phan, A Beckmann, BE Frost - Innovation in Aging, 2019 - academic.oup.com
Alzheimer’s disease (AD) is an irreversible neurodegenerative disorder which is characterized
by neurofibrillary tau tangles and amyloid-ß plaques. Our laboratory uses tau transgenic …

Spin-lattice relaxation in gaseous methane

PA Beckmann - 1971 - open.library.ubc.ca
The spin-lattice relaxation time T₁ has been measured in gaseous CH₄ as a function of
density at room temperature. The density region investigated is from 0.006 to 7.0 amagats and …