The development of increasingly biomimetic human tissue analogs has been a long-standing
goal in two important biomedical applications: drug discovery and regenerative medicine. …

The behaviour of mammalian cells in a tissue is governed by the three-dimensional (3D)
microenvironment and involves a dynamic interplay between biochemical and mechanical …

The development of new drugs is currently a long and costly process in large part due to the
failure of promising drug candidates identified in initial in vitro screens to perform as …

By binding growth factors (GFs), the ECM tightly regulates their activity. We recently reported
that the heparin-binding domain II of fibronectin acts as a promiscuous high-affinity GF-…

Three-dimensional organoid constructs serve as increasingly widespread in vitro models for
development and disease modeling. Current approaches to recreate morphogenetic …

During organogenesis, various molecular and physical signals are orchestrated in space
and time to sculpt multiple cell types into functional tissues and organs. The complex and …

Reductionist in vitro model systems which mimic specific extracellular matrix functions in a
highly controlled manner, termed artificial extracellular matrices (aECM), have increasingly …

Since the discovery of induced pluripotent stem cells (iPSCs), numerous approaches have
been explored to improve the original protocol, which is based on a two-dimensional (2D) cell…

In the context of a cellular therapy for diabetes, methods for pancreatic progenitor expansion
and subsequent differentiation into insulin-producing beta cells would be extremely …

The vascularization of engineered tissues and organoids has remained a major unresolved
challenge in regenerative medicine. While multiple approaches have been developed to …