Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of
Europe and western Asia before disappearing 30,000 years ago. We present a draft …

Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we have
sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual …

We present a DNA library preparation method that has allowed us to reconstruct a high-coverage
(30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality …

Neanderthals are the extinct hominid group most closely related to contemporary humans,
so their genome offers a unique opportunity to identify genetic changes specific to …

High-throughput direct sequencing techniques have recently opened the possibility to
sequence genomes from Pleistocene organisms. Here we analyze DNA sequences determined …

A complete mitochondrial (mt) genome sequence was reconstructed from a 38,000 year-old
Neandertal individual with 8341 mtDNA sequences identified among 4.8 Gb of DNA …

Analysis of Neandertal DNA holds great potential for investigating the population history of
this group of hominins, but progress has been limited due to the rarity of samples and …

Efficient strategies for precise genome editing in human-induced pluripotent cells (hiPSCs)
will enable sophisticated genome engineering for research and clinical purposes. The …

DNA sequences determined from ancient organisms have high error rates, primarily due to
uracil bases created by cytosine deamination. We use synthetic oligonucleotides, as well as …

The recovery of DNA sequences from early modern humans (EMHs) could shed light on
their interactions with archaic groups such as Neandertals and their relationships to current …