User profiles for Adrianne Jenner

Adrianne Jenner

Queensland University of Technology
Verified email at qut.edu.au
Cited by 586

Mathematical modelling of the interaction between cancer cells and an oncolytic virus: insights into the effects of treatment protocols

AL Jenner, CO Yun, PS Kim, ACF Coster - Bulletin of mathematical biology, 2018 - Springer
Oncolytic virotherapy is an experimental cancer treatment that uses genetically engineered
viruses to target and kill cancer cells. One major limitation of this treatment is that virus …

[HTML][HTML] COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes

AL Jenner, RA Aogo, S Alfonso, V Crowe… - PLoS …, 2021 - journals.plos.org
To understand the diversity of immune responses to SARS-CoV-2 and distinguish features
that predispose individuals to severe COVID-19, we developed a mechanistic, within-host …

Oncolytic virotherapy for tumours following a Gompertz growth law

AL Jenner, PS Kim, F Frascoli - Journal of theoretical biology, 2019 - Elsevier
Oncolytic viruses are genetically engineered to treat growing tumours and represent a very
promising therapeutic strategy. Using a Gompertz growth law, we discuss a model that …

[HTML][HTML] In silico trials predict that combination strategies for enhancing vesicular stomatitis oncolytic virus are determined by tumor aggressivity

AL Jenner, T Cassidy, K Belaid… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Original research: In silico trials predict that combination strategies for enhancing vesicular
stomatitis oncolytic virus are determined by tumor aggressivity - PMC Back to Top Skip to …

[HTML][HTML] Leveraging computational modeling to understand infectious diseases

AL Jenner, RA Aogo, CL Davis, AM Smith… - Current Pathobiology …, 2020 - Springer
Purpose of Review Computational and mathematical modeling have become a critical part
of understanding in-host infectious disease dynamics and predicting effective treatments. In …

[HTML][HTML] Optimising hydrogel release profiles for viro-immunotherapy using oncolytic adenovirus expressing IL-12 and GM-CSF with immature dendritic cells

AL Jenner, F Frascoli, CO Yun, PS Kim - Applied Sciences, 2020 - mdpi.com
Sustained-release delivery systems, such as hydrogels, significantly improve cancer therapies
by extending the treatment efficacy and avoiding excess wash-out. Combined virotherapy …

Engineering in medicine to address the challenge of cancer drug resistance: from micro-and nanotechnologies to computational and mathematical modeling

M Craig, AL Jenner, B Namgung, LP Lee… - Chemical …, 2020 - ACS Publications
Drug resistance has profoundly limited the success of cancer treatment, driving relapse,
metastasis, and mortality. Nearly all anticancer drugs and even novel immunotherapies, which …

Iterative community-driven development of a SARS-CoV-2 tissue simulator

…, R Heiland, T Hillen, D Hou, MA Islam, AL Jenner… - BioRxiv, 2020 - biorxiv.org
The 2019 novel coronavirus, SARS-CoV-2, is an emerging pathogen of critical significance
to international public health. Knowledge of the interplay between molecular-scale virus-…

Modelling combined virotherapy and immunotherapy: strengthening the antitumour immune response mediated by IL-12 and GM-CSF expression

AL Jenner, CO Yun, A Yoon… - Letters in …, 2018 - lettersinbiomath.org
Combined virotherapy and immunotherapy has been emerging as a promising and effective
cancer treatment for some time. Intratumoural injections of an oncolytic virus instigate an …

[PDF][PDF] Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy

AL Jenner, M Smalley, D Goldman, WF Goins… - Iscience, 2022 - cell.com
Oncolytic viruses (OVs) are emerging cancer immunotherapy. Despite notable successes in
the treatment of some tumors, OV therapy for central nervous system cancers has failed to …