User profiles for Adrianne Jenner
Adrianne JennerQueensland University of Technology Verified email at qut.edu.au Cited by 586 |
Mathematical modelling of the interaction between cancer cells and an oncolytic virus: insights into the effects of treatment protocols
Oncolytic virotherapy is an experimental cancer treatment that uses genetically engineered
viruses to target and kill cancer cells. One major limitation of this treatment is that virus …
viruses to target and kill cancer cells. One major limitation of this treatment is that virus …
[HTML][HTML] COVID-19 virtual patient cohort suggests immune mechanisms driving disease outcomes
To understand the diversity of immune responses to SARS-CoV-2 and distinguish features
that predispose individuals to severe COVID-19, we developed a mechanistic, within-host …
that predispose individuals to severe COVID-19, we developed a mechanistic, within-host …
Oncolytic virotherapy for tumours following a Gompertz growth law
Oncolytic viruses are genetically engineered to treat growing tumours and represent a very
promising therapeutic strategy. Using a Gompertz growth law, we discuss a model that …
promising therapeutic strategy. Using a Gompertz growth law, we discuss a model that …
[HTML][HTML] In silico trials predict that combination strategies for enhancing vesicular stomatitis oncolytic virus are determined by tumor aggressivity
Original research: In silico trials predict that combination strategies for enhancing vesicular
stomatitis oncolytic virus are determined by tumor aggressivity - PMC Back to Top Skip to …
stomatitis oncolytic virus are determined by tumor aggressivity - PMC Back to Top Skip to …
[HTML][HTML] Leveraging computational modeling to understand infectious diseases
Purpose of Review Computational and mathematical modeling have become a critical part
of understanding in-host infectious disease dynamics and predicting effective treatments. In …
of understanding in-host infectious disease dynamics and predicting effective treatments. In …
[HTML][HTML] Optimising hydrogel release profiles for viro-immunotherapy using oncolytic adenovirus expressing IL-12 and GM-CSF with immature dendritic cells
Sustained-release delivery systems, such as hydrogels, significantly improve cancer therapies
by extending the treatment efficacy and avoiding excess wash-out. Combined virotherapy …
by extending the treatment efficacy and avoiding excess wash-out. Combined virotherapy …
Engineering in medicine to address the challenge of cancer drug resistance: from micro-and nanotechnologies to computational and mathematical modeling
Drug resistance has profoundly limited the success of cancer treatment, driving relapse,
metastasis, and mortality. Nearly all anticancer drugs and even novel immunotherapies, which …
metastasis, and mortality. Nearly all anticancer drugs and even novel immunotherapies, which …
Iterative community-driven development of a SARS-CoV-2 tissue simulator
The 2019 novel coronavirus, SARS-CoV-2, is an emerging pathogen of critical significance
to international public health. Knowledge of the interplay between molecular-scale virus-…
to international public health. Knowledge of the interplay between molecular-scale virus-…
Modelling combined virotherapy and immunotherapy: strengthening the antitumour immune response mediated by IL-12 and GM-CSF expression
Combined virotherapy and immunotherapy has been emerging as a promising and effective
cancer treatment for some time. Intratumoural injections of an oncolytic virus instigate an …
cancer treatment for some time. Intratumoural injections of an oncolytic virus instigate an …
[PDF][PDF] Agent-based computational modeling of glioblastoma predicts that stromal density is central to oncolytic virus efficacy
Oncolytic viruses (OVs) are emerging cancer immunotherapy. Despite notable successes in
the treatment of some tumors, OV therapy for central nervous system cancers has failed to …
the treatment of some tumors, OV therapy for central nervous system cancers has failed to …