User profiles for Adriano Chiò
 | Adriano Chio'Professor of Neurology, 'Rita Levi Montalcini' Department of Neuroscience, University of … Verified email at unito.it Cited by 50022 |
[PDF][PDF] A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD)
locus contains one of the last major unidentified autosomal-dominant genes underlying these …
locus contains one of the last major unidentified autosomal-dominant genes underlying these …
[HTML][HTML] Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
Background The intrathecally administered antisense oligonucleotide tofersen reduces
synthesis of the superoxide dismutase 1 (SOD1) protein and is being studied in patients with …
synthesis of the superoxide dismutase 1 (SOD1) protein and is being studied in patients with …
State of play in amyotrophic lateral sclerosis genetics
Considerable progress has been made in unraveling the genetic etiology of amyotrophic
lateral sclerosis (ALS), the most common form of adult-onset motor neuron disease and the …
lateral sclerosis (ALS), the most common form of adult-onset motor neuron disease and the …
[HTML][HTML] Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
Background We aimed to accurately estimate the frequency of a hexanucleotide repeat
expansion in C9orf72 that has been associated with a large proportion of cases of amyotrophic …
expansion in C9orf72 that has been associated with a large proportion of cases of amyotrophic …
Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature
Background: Amyotrophic lateral sclerosis (ALS) is relatively rare, yet the economic and
social burden is substantial. Having accurate incidence and prevalence estimates would …
social burden is substantial. Having accurate incidence and prevalence estimates would …
Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …
by the degeneration of both upper and lower motor neurons, which leads to muscle …
[PDF][PDF] Exome sequencing reveals VCP mutations as a cause of familial ALS
Using exome sequencing, we identified a p.R191Q amino acid change in the valosin-containing
protein (VCP) gene in an Italian family with autosomal dominantly inherited amyotrophic …
protein (VCP) gene in an Italian family with autosomal dominantly inherited amyotrophic …
Prognostic factors in ALS: a critical review
We have performed a systematic review to summarize current knowledge concerning factors
related to survival in ALS and to evaluate the implications of these data for clinical trials …
related to survival in ALS and to evaluate the implications of these data for clinical trials …
Incidence of amyotrophic lateral sclerosis in Europe
Background Geographical differences in the incidence of amyotrophic lateral sclerosis (ALS)
have been reported in the literature but comparisons across previous studies are limited by …
have been reported in the literature but comparisons across previous studies are limited by …
Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players
A Chio, G Benzi, M Dossena, R Mutani, G Mora - Brain, 2005 - academic.oup.com
The cause of amyotrophic lateral sclerosis (ALS) is still unknown. A possible relationship
between ALS and sport participation has been supposed, but never definitely demonstrated. …
between ALS and sport participation has been supposed, but never definitely demonstrated. …