This paper develops the concept of graduate identity as a way of deepening the understanding
of graduate employability. It does this through presenting research in which over 100 …

Chronic cytomegalovirus (CMV) infection leads to long-term maintenance of extraordinarily
large CMV-specific T cell populations. The magnitude of this so-called ‘memory inflation’ is …

Stem cells show intrinsic interferon signalling, which protects them from viral infections at all
ages. In the ageing brain, interferon signalling also reduces the ability of stem cells to …

The regenerative capacity of hematopoietic stem cells (HSCs) is limited by the accumulation
of DNA damage. Conditional mutagenesis of the histone 3 lysine 4 (H3K4) …

A major limitation preventing in vivo modulation of hematopoietic stem cells (HSCs) is the
incomplete understanding of the cellular and molecular support of the microenvironment in …

Hematopoiesis is a paradigm for tissue development and renewal from stem cells. Experiments
show that the maintenance of hematopoietic stem cells (HSCs) relies on signals from …

Populations of stem, progenitor, or cancer cells show proliferative heterogeneity in vivo,
comprising proliferating and quiescent cells. Consistent quantification of the quiescent …

The identification and progression of a potent and selective series of isoquinoline inhibitors
of IκB kinase-β (IKK-β) are described. Hit-generation chemistry based on IKK-β active-site …

While the average cell-cycle length in a cell population can be derived from pulse-chase
experiments, proliferative heterogeneity has been difficult to quantify. Here we describe CycleF…

This chapter examines common perspectives that can help early career professionals to
understand and better manage their career, considering some of the key factors that influence …