User profiles for Adrienne W. Paton

Adrienne Paton

University of Adelaide
Verified email at adelaide.edu.au
Cited by 16920

Pathogenesis and Diagnosis of Shiga Toxin-Producing Escherichia coli Infections

JC Paton, AW Paton - Clinical microbiology reviews, 1998 - Am Soc Microbiol
Since their initial recognition 20 years ago, Shiga toxin-producing Escherichia coli (STEC)
strains have emerged as an important cause of serious human gastrointestinal disease, which …

Detection and characterization of Shiga toxigenic Escherichia coli by using multiplex PCR assays for stx 1, stx 2, eaeA, enterohemorrhagic E. coli hlyA, rfb O111, and …

AW Paton, JC Paton - Journal of clinical microbiology, 1998 - Am Soc Microbiol
Shiga toxigenic Escherichia coli (STEC) comprises a diverse group of organisms capable of
causing severe gastrointestinal disease in humans. Within the STEC family, certain strains …

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

…, P Kimmig, AS Mendez, AW Paton, JC Paton… - science, 2014 - science.org
Protein folding by the endoplasmic reticulum (ER) is physiologically critical; its disruption
causes ER stress and augments disease. ER stress activates the unfolded protein response (…

Direct Detection and Characterization of Shiga Toxigenic Escherichia coli by Multiplex PCR for stx1, stx2, eae, ehxA, and saa

AW Paton, JC Paton - Journal of Clinical Microbiology, 2002 - Am Soc Microbiol
We recently described a novel megaplasmid-encoded adhesin produced by certain Shiga
toxigenic Escherichia coli (STEC) strains that lack the locus for enterocyte effacement (LEE) …

Characterization of Saa, a Novel Autoagglutinating Adhesin Produced by Locus of Enterocyte Effacement-Negative Shiga-ToxigenicEscherichia coli Strains That Are …

AW Paton, P Srimanote, MC Woodrow… - Infection and …, 2001 - Am Soc Microbiol
The capacity of Shiga toxigenic Escherichia coli(STEC) to adhere to the intestinal mucosa
undoubtedly contributes to pathogenesis of human disease. The majority of STEC strains …

AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP

AW Paton, T Beddoe, CM Thorpe, JC Whisstock… - Nature, 2006 - nature.com
AB 5 toxins are produced by pathogenic bacteria and consist of enzymatic A subunits that
corrupt essential eukaryotic cell functions, and pentameric B subunits that mediate uptake into …

Molecular microbiological investigation of an outbreak of hemolytic-uremic syndrome caused by dry fermented sausage contaminated with Shiga-like toxin-producing …

AW Paton, RM Ratcliff, RM Doyle… - Journal of clinical …, 1996 - Am Soc Microbiol
Shiga-like toxin-producing Escherichia coli (SLTEC) strains are a diverse group of organisms
which are known to cause diarrhea and hemorrhagic colitis in humans. This can lead to …

A New Family of Potent AB5 Cytotoxins Produced by Shiga Toxigenic Escherichia coli

AW Paton, P Srimanote, UM Talbot, H Wang… - The Journal of …, 2004 - rupress.org
The Shiga toxigenic Escherichia coli (STEC) O113:H21 strain 98NK2, which was responsible
for an outbreak of hemolytic uremic syndrome, secretes a highly potent and lethal subtilase …

Molecular Characterization of a Shiga ToxigenicEscherichia coli O113:H21 Strain Lacking eaeResponsible for a Cluster of Cases of Hemolytic-Uremic Syndrome

AW Paton, MC Woodrow, RM Doyle… - Journal of clinical …, 1999 - Am Soc Microbiol
Shiga toxigenic Escherichia coli (STEC) strains are a diverse group of organisms capable of
causing severe gastrointestinal disease in humans. Within the STEC family, certain strains …

Activation of the Akt-NF-κB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response

…, S Nakajima, J Yao, AW Paton, JC Paton… - The Journal of …, 2009 - journals.aai.org
Shiga toxin has the potential to induce expression of inflammation-associated genes,
although the underlying mechanisms are not well understood. We examined the effects of …