Resistance to endocrine therapy occurs in virtually all patients with estrogen receptor α (ERα)-positive
metastatic breast cancer, and is attributed to various mechanisms including loss of …

Background This study reports on a hitherto undescribed autosomal recessive syndrome
characterised by dysmorphic features and multiple congenital anomalies together with severe …

COPII and COPI mediate the formation of membrane vesicles translocating in opposite directions
within the secretory pathway. Live-cell and electron microscopy revealed a novel mode …

The insulin-like growth factor (IGF) system plays an important role in mammary gland biology
as well as in the etiology of breast cancer. The IGF-I receptor (IGF-IR), which mediates the …

Ca +2 -dependent exocytosis involves vesicle docking, priming, fusion, and recycling. This
process is performed and regulated by a vast number of synaptic proteins and depends on …

Activity-dependent neuroprotective protein (ADNP) is essential for brain formation and
function. As such, de novo mutations in ADNP lead to the autistic ADNP syndrome and somatic …

10.7554/eLife.34843.001 How proteins harness mechanical force to control function is a
significant biological question. Here we describe a human cell surface receptor that couples …

Background: Neutrophil migration is critical to the initiation and resolution of inflammation.
Macrophage-1 antigen (Mac-1; CD11b/CD18, αMβ2) is a leukocyte integrin essential for firm …

Avian reovirus (ARV) causes viral arthritis, tenosynovitis, liver infection and immunosuppression
in birds. Live-attenuated and inactivated vaccines for ARV are available, but do not …

Klotho is a transmembrane protein containing two internal repeats, KL1 and KL2, both
displaying significant homology to members of the β-glycosidase family. Klotho is expressed in …