Background Gastric cancer (GC) has been considered as the 5th most common type of
cancer and the third leading cause of cancer-associated death worldwide. The aim of this …

Background Large numbers of autosomal sites are found differentially methylated in the
aging genome. Due to analytical difficulties in dealing with sex differences in X-chromosome …

Background Immunosuppressive treatment of kidney transplant recipients is mainly aimed
at pro-inflammatory T effector cells, yet they also target the immunosuppressive T regulatory …

Objective Body mass index (BMI) serves as an important measurement of obesity and
adiposity, which are highly correlated with cardiometabolic diseases. Although high heritability …

Background Epigenetic inactivation of O 6 -methylguanine DNA-methyltransferase (MGMT)
is associated with increased sensitivity to alkylating chemotherapeutic agents in …

Cognitive aging is one of the major problems worldwide, especially as people get older.
This study aimed to perform global gene expression profiling of cognitive function to identify …

Privileged by rapid increase in available epigenomic data, epigenome‐wide association
studies (EWAS) are to make a profound contribution to understand the molecular mechanism of …

Background Progressive decline of allograft function leads to premature graft loss. Forkhead
box P3 (FOXP3), a characteristic gene of T-regulatory cells, is known to be essential for auto…

Introduction Comprehensive geriatric assessment (CGA) has been shown to reduce frailty
in older patients in general. In older patients with cancer, frailty affects quality of life (QoL), …

Acute myocardial infarction (AMI) is a major cause of mortality and morbidity worldwide, yet
biomarkers for AMI in the short- or medium-term are lacking. We apply the discordant twin …