Pharmacological activation of myosin II paralogs to correct cell mechanics defects

…, Q Zhu, Y Ren, LB Avery, AK Krenc… - Proceedings of the …, 2015 - National Acad Sciences
Current approaches to cancer treatment focus on targeting signal transduction pathways.
Here, we develop an alternative system for targeting cell mechanics for the discovery of novel …

Myosin light chain kinase steady‐state kinetics: comparison of smooth muscle myosin II and nonmuscle myosin IIB as substrates

…, RK Brizendine, AK Krenc… - Cell biochemistry …, 2016 - Wiley Online Library
Myosin light chain kinase (MLCK) phosphorylates S19 of the myosin regulatory light chain (RLC),
which is required to activate myosin's ATPase activity and contraction. Smooth …

A FLIC motility assay reveals myosin-6 coordination limited by actin filament buckling

AK Krenc, JJ Rokicka, RS Rock - bioRxiv, 2016 - biorxiv.org
Teams of myosin motors carry out intracellular transport and contract the actin cytoskeleton.
To fully understand the behavior of multi-myosin ensembles we need to know the properties …

[PDF][PDF] Fluorescence Interference Contrast Microscopy (FLIC)-A New Tool to Study the Collective Motor Dynamics

AK Krenc, J Rokicka, RS Rock - Biophysical Journal, 2016 - cell.com
Further development of an accurate model of actomyosin network function requires detailed
knowledge of the interaction between actin and myosin. The majority of data demonstrating …

FLUORESCENCE INTERFERENCE CONTRAST MICROSCOPY, A NEW TOOL TO STUDY COLLECTIVE MOTOR DYNAMICS

AK Krenc - 2016 - knowledge.uchicago.edu
Teams of molecular motors called myosins carry out intracellular transport and contract the
actin cytoskeleton. To fully understand the behavior of multi-myosin ensembles we need to …

[PDF][PDF] Comparing the Motility of Myosin X with Parallel and Anti-Parallel Dimerization Domains

MA Caporizzo, CE Fishman, O Sato, M Ikebe… - Biophysical …, 2016 - cell.com
… 3043-Pos Board B420 Fluorescence Interference Contrast Microscopy (FLIC) - A New Tool
to Study the Collective Motor Dynamics Agata K. Krenc, Jagoda Rokicka, Ronald S. Rock. …

[PDF][PDF] Dynamic Actin Networks Utilized to Support Simultaneous Processive Motility of Two Different Myosin Motor Classes

A Santos, RS Rock - Biophysical Journal, 2016 - cell.com
… 3043-Pos Board B420 Fluorescence Interference Contrast Microscopy (FLIC) - A New Tool
to Study the Collective Motor Dynamics Agata K. Krenc, Jagoda Rokicka, Ronald S. Rock. …

[PDF][PDF] Dynamic Instability Emerges from Micromechanics and Chemical Kinetics of Microtubule Protofilaments

I Jain, R Padinhateeri - Biophysical Journal, 2016 - cell.com
… 3043-Pos Board B420 Fluorescence Interference Contrast Microscopy (FLIC) - A New Tool
to Study the Collective Motor Dynamics Agata K. Krenc, Jagoda Rokicka, Ronald S. Rock. …

[PDF][PDF] Measuring the on-Rate of Membrane-Cytoskeleton Bonds at the Near-Equilibrium Region

V Rajasekharan, VKA Sreenivasan, JN Myers… - Biophysical …, 2016 - cell.com
… 3043-Pos Board B420 Fluorescence Interference Contrast Microscopy (FLIC) - A New Tool
to Study the Collective Motor Dynamics Agata K. Krenc, Jagoda Rokicka, Ronald S. Rock. …

[PDF][PDF] Myosin 19 is an Outer Mitochondrial Membrane Motor and Effector of Starvation Induced Filopodia with Unique Kinetic Features

A Henn, B Shneyer, M Usaj - Biophysical Journal, 2016 - cell.com
… 3043-Pos Board B420 Fluorescence Interference Contrast Microscopy (FLIC) - A New Tool
to Study the Collective Motor Dynamics Agata K. Krenc, Jagoda Rokicka, Ronald S. Rock. …