The dia-PASEF technology uses ion mobility separation to reduce signal interferences and
increase sensitivity in proteomic experiments. Here we present a two-dimensional peak-…

Proteasome-catalyzed peptide splicing (PCPS) represents an additional activity of mammalian
20S proteasomes recently identified in connection with antigen presentation. We show …

The proteasome, the central protease of eukaryotic cells, is composed of one core particle (CP)
and one or two adjacent regulatory particles (RP), which contain multiple subunits. …

Ascariasis is a widespread soil-transmitted helminth infection caused by the intestinal
roundworm Ascaris lumbricoides in humans, and the closely related Ascaris suum in pigs. …

β-Barrel proteins constitute a distinct class of mitochondrial outer membrane proteins. For
import into mitochondria, their precursor forms engage the TOM complex. They are then …

Essential precursors of the cocoa-specific aroma notes are formed during fermentation of the
cocoa beans by acid-induced proteolysis. It has been shown that, in addition to free amino …

Osteopontin is a pleiotropic cytokine that is involved in several diseases including multiple
sclerosis. Secreted osteopontin is cleaved by few known proteases, modulating its pro-…

Particular peptides generated from the vicilin-class(7S) globulin of the cocoa beans by acid-induced
proteolysis during cocoa fermentation are essential precursors of the cocoa-specific …

An efficient immunosurveillance of CD8 + T cells in the periphery depends on positive/negative
selection of thymocytes and thus on the dynamics of antigen degradation and epitope …

Immunomodulation of airway hyperreactivity by excretory-secretory (ES) products of the first
larval stage (L1) of the gastrointestinal nematode Trichuris suis is reported by us and others. …