Mammalian CELF/Bruno-like RNA-binding proteins: molecular characteristics and biological functions
C Barreau, L Paillard, A Méreau, HB Osborne - Biochimie, 2006 - Elsevier
In mammals, the CELF/Bruno-like family of RNA-binding proteins contains six members.
The founder members of the family are the CUG-BP1 (CELF1) and ETR-3 (CELF2) proteins. …
The founder members of the family are the CUG-BP1 (CELF1) and ETR-3 (CELF2) proteins. …
An in vivo and in vitro structure-function analysis of the Saccharomyces cerevisiae U3A snoRNP: protein-RNA contacts and base-pair interaction with the pre …
A Méreau, R Fournier, A Grégoire, A Mougin… - Journal of molecular …, 1997 - Elsevier
The structure and accessibility of the S. cerevisiae U3A snoRNA was studied in semi-purified
U3A snoRNPs using both chemical and enzymatic probes and in vivo using DMS as the …
U3A snoRNPs using both chemical and enzymatic probes and in vivo using DMS as the …
[HTML][HTML] Bioinformatic prediction, deep sequencing of microRNAs and expression analysis during phenotypic plasticity in the pea aphid, Acyrthosiphon pisum
…, K Gordon, D Lavenier, N Leterme, A Méreau… - BMC genomics, 2010 - Springer
Background Post-transcriptional regulation in eukaryotes can be operated through
microRNA (miRNAs) mediated gene silencing. MiRNAs are small (18-25 nucleotides) non-coding …
microRNA (miRNAs) mediated gene silencing. MiRNAs are small (18-25 nucleotides) non-coding …
A Janus splicing regulatory element modulates HIV-1 tat and rev mRNA production by coordination of hnRNP A1 cooperative binding
V Marchand, A Méreau, S Jacquenet, D Thomas… - Journal of molecular …, 2002 - Elsevier
Retroviral protein production depends upon alternative splicing of the viral transcript. The
HIV-1 acceptor site A7 is required for tat and rev mRNA production. Production of the Tat …
HIV-1 acceptor site A7 is required for tat and rev mRNA production. Production of the Tat …
[HTML][HTML] A second exon splicing silencer within human immunodeficiency virus type 1 tat exon 2 represses splicing of Tat mRNA and binds protein hnRNP H
S Jacquenet, A Méreau, PS Bilodeau, L Damier… - Journal of Biological …, 2001 - ASBMB
An equilibrium between spliced and unspliced primary transcripts is essential for retrovirus
multiplication. This equilibrium is maintained by the presence of inefficient splice sites. The …
multiplication. This equilibrium is maintained by the presence of inefficient splice sites. The …
[HTML][HTML] The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development
…, A Kakrana, CA Dang, V Legagneux, A Méreau… - PLoS …, 2018 - journals.plos.org
Opacification of the ocular lens, termed cataract, is a common cause of blindness. To become
transparent, lens fiber cells undergo degradation of their organelles, including their nuclei, …
transparent, lens fiber cells undergo degradation of their organelles, including their nuclei, …
[HTML][HTML] DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6. U5 tri-snRNP assembly and pre-mRNA splicing fidelity
A Duchemin, T O'grady, S Hanache, A Mereau… - Nature …, 2021 - nature.com
The U6 snRNA, the core catalytic component of the spliceosome, is extensively modified
post-transcriptionally, with 2’-O-methylation being most common. However, how U6 2’-O-…
post-transcriptionally, with 2’-O-methylation being most common. However, how U6 2’-O-…
[HTML][HTML] A Point Mutation in a lincRNA Upstream of GDNF Is Associated to a Canine Insensitivity to Pain: A Spontaneous Model for Human Sensory Neuropathies
Human Hereditary Sensory Autonomic Neuropathies (HSANs) are characterized by insensitivity
to pain, sometimes combined with self-mutilation. Strikingly, several sporting dog breeds …
to pain, sometimes combined with self-mutilation. Strikingly, several sporting dog breeds …
Implication of the SMN complex in the biogenesis and steady state level of the signal recognition particle
…, S Lefebvre, M Dodre, A Mereau… - Nucleic acids …, 2013 - academic.oup.com
Spinal muscular atrophy is a severe motor neuron disease caused by reduced levels of the
ubiquitous Survival of MotoNeurons (SMN) protein. SMN is part of a complex that is essential …
ubiquitous Survival of MotoNeurons (SMN) protein. SMN is part of a complex that is essential …
The RNA-binding proteins CELF1 and ELAVL1 cooperatively control the alternative splicing of CD44
G David, D Reboutier, S Deschamps, A Méreau… - Biochemical and …, 2022 - Elsevier
CD44 mRNA contains nine consecutive cassette exons, v2 to v10. Upon alternative splicing,
several isoforms are produced with different impacts on tumor biology. Here, we …
several isoforms are produced with different impacts on tumor biology. Here, we …