Tumor protein p53 (TP53) is the most frequently mutated gene in cancer 1 , 2 . In patients with
myelodysplastic syndromes (MDS), TP53 mutations are associated with high-risk disease …

We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …

By means of in vivo selection, transcriptomic analysis, functional verification and clinical
validation, here we identify a set of genes that marks and mediates breast cancer metastasis to …

Background Acute myeloid leukemia (AML) is a heterogeneous disease with respect to
presentation and clinical outcome. The prognostic value of recently identified somatic mutations …

Both genome-wide genetic and epigenetic alterations are fundamentally important for the
development of cancers, but the interdependence of these aberrations is poorly understood. …

In human lung adenocarcinomas harboring EGFR mutations, a second-site point mutation
that substitutes methionine for threonine at position 790 (T790M) is associated with …

The gastrointestinal tracts of mammals are colonized by hundreds of microbial species that
contribute to health, including colonization resistance against intestinal pathogens 1 . Many …

Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific
mortality. Using whole-exome and targeted sequencing, we find that truncating …

Venous malformations (VM) are vascular malformations characterized by enlarged and
distorted blood vessel channels. VM grow over time and cause substantial morbidity because of …

The isolation of human induced pluripotent stem cells (iPSCs) 1 , 2 , 3 offers a new strategy
for modelling human disease. Recent studies have reported the derivation and differentiation …