Key points Regulation of autophagy in human muscle in many aspects differs from the majority
of previous reports based on studies in cell systems and rodent muscle. An acute bout of …

Understanding how muscle contraction orchestrates insulin-independent muscle glucose
transport may enable development of hyperglycemia-treating drugs. The prevailing concept …

AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis, acting
as a sensor of energy and nutrient status. As such, AMPK is considered a promising drug …

The small molecule kinase inhibitor SBI-0206965 was originally described as a specific inhibitor
of ULK1/2. More recently, it was reported to effectively inhibit AMPK and several studies …

Studies in skeletal muscle cell cultures suggest that the cortical actin cytoskeleton is a major
requirement for insulin-stimulated glucose transport, implicating the β-actin isoform, which in …

Key points Muscle‐specific genetic ablation of p21‐activated kinase (PAK)2, but not whole‐body
PAK1 knockout, impairs glucose tolerance in mice. Insulin‐stimulated glucose uptake …

The cortical cytoskeleton, consisting of the cytoplasmic actin isoforms β and/or γ‐actin, has
been implicated in insulin‐stimulated GLUT4 translocation and glucose uptake in muscle and …

Botulinum toxin A (botox) is a toxin used for spasticity treatment and cosmetic purposes.
Botox blocks the excitation of skeletal muscle fibers by preventing the release of acetylcholine …

A low‐protein high carbohydrate ( LPHC ) diet and a high‐protein low carbohydrate ( HPLC
) diet have been reported to positively and negatively regulate whole‐body glucose …

Objective Skeletal muscle glucose uptake is essential for maintaining whole-body glucose
homeostasis and accounts for the majority of glucose disposal in response to insulin. The …