Smaug1 membrane-less organelles respond to AMPK and mTOR and affect mitochondrial function

…, M Habif, J Pimentel, AA Corbat… - Journal of Cell …, 2022 - journals.biologists.com
Smaug is a conserved translational regulator that binds numerous mRNAs, including nuclear
transcripts that encode mitochondrial enzymes. Smaug orthologs form cytosolic membrane-…

Spatially segregated defects and IGF1‐responsiveness of hilar and peripheral biliary organoids from a model of Alagille syndrome

A Iqbal, N Van Hul, L Belicova, AA Corbat… - Liver …, 2024 - Wiley Online Library
Background & Aims Alagille syndrome (ALGS) manifests with peripheral intrahepatic bile duct
(IHBD) paucity, which can spontaneously resolve. In a model for ALGS, Jag1 Ndr/Ndr mice…

Caspam: a triple-modality biosensor for multiplexed imaging of caspase network activity

M Habif, AA Corbat, M Silberberg, HE Grecco - ACS sensors, 2021 - ACS Publications
Understanding signal propagation across biological networks requires to simultaneously
monitor the dynamics of several nodes to uncover correlations masked by inherent intercellular …

[HTML][HTML] Co-imaging extrinsic, intrinsic and effector caspase activity by fluorescence anisotropy microscopy

AA Corbat, KC Schuermann, P Liguzinski, Y Radon… - Redox biology, 2018 - Elsevier
In order to overcome intercellular variability and thereby effectively assess signal propagation
in biological networks it is imperative to simultaneously quantify multiple biological …

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial compartment of the developing cochlea

S de Haan, AA Corbat, CR Cederroth, LG Autrum… - bioRxiv, 2024 - biorxiv.org
Notch signaling regulates both inner and middle ear morphogenesis and establishes a strict
pattern of sensory cells in the organ of Corti in the mammalian cochlea. Patients with …

An Integrative Apoptotic Reaction Model for extrinsic and intrinsic stimuli

AA Corbat, M Silberberg, HE Grecco - bioRxiv, 2021 - biorxiv.org
Apoptosis, a form of programmed cell death central to all multicellular organisms, plays a key
role during organism development and is often misregulated in cancer. Devising a single …

Smaug membraneless organelles regulate mitochondrial function

…, ML Pascual, M Habif, J Pimentel, AA Corbat… - bioRxiv, 2020 - biorxiv.org
Smaug is a conserved translational repressor that recognizes specific RNA motifs in a large
number of mRNAs, including nuclear transcripts that encode mitochondrial enzymes. Smaug …

Molten Globule Driven and Self-downmodulated Phase Separation of a Viral Factory Scaffold: Phase separation of a viral replication scaffold

…, M Aran, LA Pellizza Pena, S Esperante, AA Corbat… - 2023 - ri.conicet.gov.ar
Viral factories of liquid-like nature serve as sites for transcription and replication in most viruses.
The respiratory syncytial virus factories include replication proteins, brought together by …

[PDF][PDF] LEC

M Silberberg, AA Corbat, HE Grecco - users.df.uba.ar
Co-measuring activity of three caspases with live single-cell imaging Page 1 Find me at :
https://github.com/maurosilber/cellment Co-measuring activity of three caspases with live …

Molten globule driven and self-downmodulated phase separation of a viral factory scaffold

…, M Aran, L Pellizza, SA Esperante, A Corbat… - Journal of Molecular …, 2023 - Elsevier
Viral factories of liquid-like nature serve as sites for transcription and replication in most viruses.
The respiratory syncytial virus factories include replication proteins, brought together by …