Purpose Survival and progression of mature B-cell malignancies depend on signals from
the B-cell antigen receptor, and Bruton tyrosine kinase (BTK) is a critical signaling kinase in …

B-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL).
Bruton tyrosine kinase (BTK) is essential to BCR signaling and in knockout mouse models …

Background Irreversible inhibition of Bruton’s tyrosine kinase (BTK) by ibrutinib represents
an important therapeutic advance for the treatment of chronic lymphocytic leukemia (CLL). …

PURPOSE Among Bruton's tyrosine kinase inhibitors, acalabrutinib has greater selectivity
than ibrutinib, which we hypothesized would improve continuous therapy tolerability. We …

Background Chemoimmunotherapy has led to improved numbers of patients achieving
disease response, and longer overall survival in young patients with chronic lymphocytic …

BACKGROUND: Cardiac surgery with cardiopulmonary bypass may result in excessive
fibrinolysis and platelet (PLT) dysfunction, resulting in impaired hemostasis and excessive blood …

Background Bruton tyrosine kinase is a clinically validated target in mantle cell lymphoma.
Acalabrutinib (ACP-196) is a highly selective, potent Bruton tyrosine kinase inhibitor …

Patients with severe COVID-19 have a hyperinflammatory immune response suggestive of
macrophage activation. Bruton tyrosine kinase (BTK) regulates macrophage signaling and …

Since the emergence of Soluplus® (SOL) as a commercial graft copolymer, multiple
publications have been issued on its promising potential as a solubilizing excipient that could …

Previous studies in patients with Parkinson's disease have reported that a single session of
repetitive transcranial magnetic stimulation (rTMS) can improve some or all of the motor …