Zika virus is a member of the Flavivirus genus that had not been associated with severe disease
in humans until the recent outbreaks, when it was linked to microcephaly in newborns in …

The availability of whole-genome sequence data, made possible by significant advances in
DNA sequencing technology, led to the emergence of structural genomics projects in the late …

Pentameric ligand-gated ion channels mediate fast chemical transmission of nerve signals.
The structure of a bacterial proton-gated homolog has been established in its open and …

The chemical synthesis of new compounds designed as inhibitors of Mycobacterium tuberculosis
TMP kinase (TMPK) is reported. The synthesis concerns TMP analogues modified at …

Dengue disease is caused by four different flavivirus 1 serotypes, which infect 390 million
people yearly with 25% symptomatic cases 2 and for which no licensed vaccine is available. …

Temperature sensing is essential for the survival of living cells. A major challenge is to
understand how a biological thermometer processes thermal information to optimize cellular …

Mitochondria play a key role in apoptosis due to their capacity to release potentially lethal
proteins. One of these latent death factors is cytochrome c, which can stimulate the proteolytic …

Cell-cell fusion proteins are essential in development. Here we show that the C. elegans cell-cell
fusion protein EFF-1 is structurally homologous to viral class II fusion proteins. The 2.6 …

Cells have two purine pathways that synthesize adenine and guanine ribonucleotides from
phosphoribose via inosylate. A chemical hybrid between adenine and guanine, 2-…

Nucleic acid aptamers selected through systematic evolution of ligands by exponential
enrichment (SELEX) fold into exquisite globular structures in complex with protein targets with …