User profiles for Ahmet Hoke

Ahmet Hoke

Professor of Neurology and Neuroscience, Johns Hopkins University
Verified email at jhmi.edu
Cited by 17627

Advances in peripheral nerve regeneration

J Scheib, A Höke - Nature Reviews Neurology, 2013 - nature.com
Rodent models of nerve injury have increased our understanding of peripheral nerve
regeneration, but clinical applications have been scarce, partly because such models do not …

Aligned protein–polymer composite fibers enhance nerve regeneration: A potential tissue‐engineering platform

SY Chew, R Mi, A Hoke… - Advanced functional …, 2007 - Wiley Online Library
Sustained release of proteins from aligned polymeric fibers holds great potential in tissue‐engineering
applications. These protein–polymer composite fibers possess high surface‐area…

Mechanisms of Disease: what factors limit the success of peripheral nerve regeneration in humans?

A Höke - Nature clinical practice Neurology, 2006 - nature.com
Functional recovery after repair of peripheral nerve injury in humans is often suboptimal. Over
the past quarter of a century, there have been significant advances in human nerve repair, …

Schwann cells express motor and sensory phenotypes that regulate axon regeneration

A Höke, R Redett, H Hameed, R Jari… - Journal of …, 2006 - Soc Neuroscience
Schwann cell phenotype is classified as either myelinating or nonmyelinating. Additional
phenotypic specialization is suggested, however, by the preferential reinnervation of muscle …

Programmed axon degeneration: from mouse to mechanism to medicine

MP Coleman, A Höke - Nature Reviews Neuroscience, 2020 - nature.com
Wallerian degeneration is a widespread mechanism of programmed axon degeneration. In
the three decades since the discovery of the Wallerian degeneration slow (Wld S ) mouse, …

Mechanisms of distal axonal degeneration in peripheral neuropathies

CR Cashman, A Höke - Neuroscience letters, 2015 - Elsevier
Peripheral neuropathy is a common complication of a variety of diseases and treatments,
including diabetes, cancer chemotherapy, and infectious causes (HIV, hepatitis C, and …

A framework for diagnosing and classifying intensive care unit-acquired weakness

…, SA Marshall, DR Cornblath, A Hoke… - Critical care …, 2009 - journals.lww.com
Neuromuscular dysfunction is prevalent in critically ill patients, is associated with worse
short-term outcomes, and is a determinant of long-term disability in intensive care unit survivors. …

Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis

P Mohassel, S Donkervoort, MA Lone, M Nalls… - Nature medicine, 2021 - nature.com
Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disease of the lower
and upper motor neurons with sporadic or hereditary occurrence. Age of onset, pattern of …

[HTML][HTML] Differences between human and mouse embryonic stem cells

…, R Brandenberger, S Gerecht-Nir, M Amit, A Hoke… - Developmental …, 2004 - Elsevier
We compared gene expression profiles of mouse and human ES cells by immunocytochemistry,
RT-PCR, and membrane-based focused cDNA array analysis. Several markers that in …

Sensory neuropathy in human immunodeficiency virus/acquired immunodeficiency syndrome patients: Protease inhibitor–mediated neurotoxicity

…, HB Krentz, OT Keppler, A Hoke… - Annals of Neurology …, 2006 - Wiley Online Library
Objective Human immunodeficiency virus–associated sensory neuropathy (HIV‐SN) is a
common and disabling disorder, often associated with antiretroviral therapy (ART) use. We …