User profiles for Aiden Corvin
Prof. Aiden CorvinTrinity College Dublin Verified email at tcd.ie Cited by 67398 |
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
…, H Gurling, DHR Blackwood, A Corvin… - Nature, 2009 - nature.com
Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80% 1 , 2 . …
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80% 1 , 2 . …
[HTML][HTML] Brain charts for the human lifespan
…, G Chetelat, YS Chong, JH Cole, A Corvin… - Nature, 2022 - nature.com
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research
and clinical studies of the human brain. However, no reference standards currently exist to …
and clinical studies of the human brain. However, no reference standards currently exist to …
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases
and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10 −…
and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10 −…
Rare coding variants in ten genes confer substantial risk for schizophrenia
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …
Identification of loci associated with schizophrenia by genome-wide association and follow-up
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls)
and tested loci with P < 10 −5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 …
and tested loci with P < 10 −5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 …
[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …
become more accurate as training sample sizes increase. The standard approach for …
[HTML][HTML] Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium
The profile of brain structural abnormalities in schizophrenia is still not fully understood,
despite decades of research using brain scans. To validate a prospective meta-analysis …
despite decades of research using brain scans. To validate a prospective meta-analysis …
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
…, A Christoforou, ET Cirulli, E Congdon, A Corvin… - Nature …, 2018 - nature.com
Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …
[HTML][HTML] Genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
(WTCCC2) consortia is provided in the Supplementary Note online. Author Contributions FC,
ADB, CEMG, J. Kere., A. Reis, JNB and RCT oversaw cohort collection for both the …
ADB, CEMG, J. Kere., A. Reis, JNB and RCT oversaw cohort collection for both the …
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting
the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. …
the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. …