User profiles for Aiden Corvin

Prof. Aiden Corvin

Trinity College Dublin
Verified email at tcd.ie
Cited by 67398

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

…, H Gurling, DHR Blackwood, A Corvin… - Nature, 2009 - nature.com
Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by
hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80% 1 , 2 . …

[HTML][HTML] Brain charts for the human lifespan

…, G Chetelat, YS Chong, JH Cole, A Corvin… - Nature, 2022 - nature.com
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research
and clinical studies of the human brain. However, no reference standards currently exist to …

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

…, EM Scolnick, P McGuffin, MJ Daly, AP Corvin… - Nature …, 2008 - nature.com
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases
and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10 −…

Rare coding variants in ten genes confer substantial risk for schizophrenia

…, DH Blackwood, AD Børglum, BM Cohen, AP Corvin… - Nature, 2022 - nature.com
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

Identification of loci associated with schizophrenia by genome-wide association and follow-up

…, PV Gejman, S Cichon, MM Nöthen, M Gill, A Corvin… - Nature …, 2008 - nature.com
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls)
and tested loci with P < 10 −5 in up to 16,726 additional subjects. Of 12 loci followed up, 3 …

[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores

…, R Do, T Hayeck, HH Won, BM Neale, A Corvin… - The american journal of …, 2015 - cell.com
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

[HTML][HTML] Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

…, C McDonald, DW Morris, DM Cannon, A Corvin… - Molecular …, 2016 - nature.com
The profile of brain structural abnormalities in schizophrenia is still not fully understood,
despite decades of research using brain scans. To validate a prospective meta-analysis …

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

…, A Christoforou, ET Cirulli, E Congdon, A Corvin… - Nature …, 2018 - nature.com
Intelligence is highly heritable 1 and a major determinant of human health and well-being 2
. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in …

[HTML][HTML] Genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

…, SJ Bumpstead, JP Casas, MJ Cork, A Corvin… - Nature …, 2010 - ncbi.nlm.nih.gov
(WTCCC2) consortia is provided in the Supplementary Note online. Author Contributions FC,
ADB, CEMG, J. Kere., A. Reis, JNB and RCT oversaw cohort collection for both the …

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

…, E Bramon, SJ Bumpstead, JP Casas, A Corvin… - Nature …, 2011 - nature.com
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting
the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. …