User profiles for Ailong Ke
 | Ailong KeRobert J. Appel Professor in Molecular Biology and Genetics, Cornell University Verified email at cornell.edu Cited by 4556 |
Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation
CRISPR drives prokaryotic adaptation to invasive nucleic acids such as phages and
plasmids, using an RNA-mediated interference mechanism. Interference in type I CRISPR-Cas …
plasmids, using an RNA-mediated interference mechanism. Interference in type I CRISPR-Cas …
Structure basis for RNA-guided DNA degradation by Cascade and Cas3
INTRODUCTION Type I CRISPR-Cas, the most prevalent CRISPR system, features a sequential
target-searching and -degradation process. First, the multisubunit surveillance complex …
target-searching and -degradation process. First, the multisubunit surveillance complex …
[PDF][PDF] Structure basis for directional R-loop formation and substrate handover mechanisms in type I CRISPR-Cas system
Type I CRISPR systems feature a sequential dsDNA target searching and degradation process,
by crRNA-displaying Cascade and nuclease-helicase fusion enzyme Cas3, respectively. …
by crRNA-displaying Cascade and nuclease-helicase fusion enzyme Cas3, respectively. …
Crystallization of RNA and RNA–protein complexes
RNA plays a direct role in a variety of cellular activities, and in many cases its biological
function is conferred by the RNA three-dimensional structure. X-ray crystallography is the …
function is conferred by the RNA three-dimensional structure. X-ray crystallography is the …
A conformational switch controls hepatitis delta virus ribozyme catalysis
Ribozymes enhance chemical reaction rates using many of the same catalytic strategies as
protein enzymes. In the hepatitis delta virus (HDV) ribozyme, site-specific self-cleavage of …
protein enzymes. In the hepatitis delta virus (HDV) ribozyme, site-specific self-cleavage of …
[PDF][PDF] Cas5d protein processes pre-crRNA and assembles into a cascade-like interference complex in subtype IC/Dvulg CRISPR-Cas system
Clustered regularly interspaced short palindromic repeats (CRISPRs), together with an
operon of CRISPR-associated (Cas) proteins, form an RNA-based prokaryotic immune system …
operon of CRISPR-associated (Cas) proteins, form an RNA-based prokaryotic immune system …
Structural basis for promiscuous PAM recognition in type I–E Cascade from E. coli
…, K Rajashankar, S Bailey, B Wiedenheft, A Ke - Nature, 2016 - nature.com
Clustered regularly interspaced short palindromic repeats (CRISPRs) and the cas (CRISPR-associated)
operon form an RNA-based adaptive immune system against foreign genetic …
operon form an RNA-based adaptive immune system against foreign genetic …
Crystal structures of the SAM-III/SMK riboswitch reveal the SAM-dependent translation inhibition mechanism
Three distinct classes of S-adenosyl-L-methionine (SAM)-responsive riboswitches have been
identified that regulate bacterial gene expression at the levels of transcription attenuation …
identified that regulate bacterial gene expression at the levels of transcription attenuation …
Craspase is a CRISPR RNA-guided, RNA-activated protease
The CRISPR-Cas type III-E RNA-targeting effector complex gRAMP/Cas7-11 is associated
with a caspase-like protein (TPR-CHAT/Csx29) to form Craspase (CRISPR-guided caspase). …
with a caspase-like protein (TPR-CHAT/Csx29) to form Craspase (CRISPR-guided caspase). …
The crystal structure of the signal recognition particle in complex with its receptor
Cotranslational targeting of membrane and secretory proteins is mediated by the universally
conserved signal recognition particle (SRP). Together with its receptor (SR), SRP mediates …
conserved signal recognition particle (SRP). Together with its receptor (SR), SRP mediates …