Epithelial-mesenchymal feedback signaling is the key to diverse organogenetic processes
such as limb bud development and branching morphogenesis in kidney and lung rudiments. …

The molecular analysis of limb bud development in vertebrates continues to fuel our
understanding of the gene regulatory networks that orchestrate the patterning, proliferation and …

Outgrowth and patterning of the vertebrate limb are controlled by reciprocal interactions
between the posterior mesenchyme (polarizing region) and a specialized ectodermal structure, …

The limb bud is of paradigmatic value to understanding vertebrate organogenesis. Recent
genetic analysis in mice has revealed the existence of a largely self-regulatory limb bud …

Turner syndrome is characterized by short stature and is frequently associated with a variable
spectrum of somatic features including ovarian failure, heart and renal abnormalities, …

The essential roles of SHH in anteroposterior (AP) and AER-FGF signalling in proximodistal
(PD) limb bud development are well understood. In addition, these morphoregulatory …

Distal limb development and specification of digit identities in tetrapods are under the control
of a mesenchymal organizer called the polarizing region. Sonic Hedgehog (SHH) is the …

The spine apparatus is a cellular organelle that is present in many dendritic spines of excitatory
neurons in the mammalian forebrain. Despite its discovery >40 years ago, the function of …

Embryogenesis depends on self-regulatory interactions between spatially separated signaling
centers, but few of these are well understood. Limb development is regulated by epithelial…

Dickkopf-1 (dkk-1) is member of a novel family of secreted proteins and functions in head
induction during Xenopus embryogenesis, acting as a potent inhibitor of Wnt signalling. Here …