The Blu-Ice and Distributed Control System (DCS) software packages were developed to
provide unified control over the disparate hardware resources available at a macromolecular …

Iron–sulfur (Fe–S) proteins are key players in vital processes involving energy homeostasis
and metabolism from the simplest to most complex organisms. We report a 1.5 Å x-ray …

Synaptotagmin-1 and neuronal SNARE proteins have central roles in evoked synchronous
neurotransmitter release; however, it is unknown how they cooperate to trigger synaptic …

An automated system for mounting and dismounting pre-frozen crystals has been
implemented at the Stanford Synchrotron Radiation Laboratory (SSRL). It is based on a small …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within
the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate–…

10.7554/eLife.07574.001 Determining the interconverting conformations of dynamic proteins
in atomic detail is a major challenge for structural biology. Conformational heterogeneity in …

The emerging method of femtosecond crystallography (FX) may extend the diffraction
resolution accessible from small radiation-sensitive crystals and provides a means to determine …

The advent of biocatalysts designed computationally and optimized by laboratory evolution
provides an opportunity to explore molecular strategies for augmenting catalytic function. …

The endoplasmic reticulum protein Miner1 is essential for health and longevity. Mis-splicing
of CISD2, which codes for Miner1, is causative in Wolfram Syndrome 2 (WFS2) resulting in …

X-ray free-electron lasers (XFELs) provide very intense X-ray pulses suitable for macromolecular
crystallography. Each X-ray pulse typically lasts for tens of femtoseconds and the …