Extrachromosomal circular DNAs (eccDNAs) are somatically mosaic and contribute to
intercellular heterogeneity in normal and tumor cells. Because short eccDNAs are poorly …

OBJECTIVE Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) has been
adopted as an alternative technique to hasten recovery and minimize postoperative …

The pathogenesis of intracranial aneurysms remains complex and multifactorial. While
vascular, genetic, and epidemiological factors play a role, nascent aneurysm formation is …

Diffuse low-grade and intermediate-grade gliomas (together known as lower grade gliomas,
WHO grade II and III) develop in the supporting glial cells of brain and are the most common …

… Chatrath. We acknowledge the MAPS core facility at University of Virginia and Tiffany
Melhuish-Baxter for help with the mouse xenograft experiment, M. Murat Koseoglu and Róża K. …

BACKGROUND Atypical and anaplastic meningiomas have reduced progression-free/overall
survival (PFS/OS) compared to benign meningiomas. Stereotactic radiosurgery (SRS) for …

… Mastorakos, Panagiotis MD, PhD; Xu, Zhiyuan MD; Yu, James MD, MHS; Hess, Judith MD;
Qian, Jack MD; Chatrath, Ajay BS; Taylor, Davis G MD; Kondziolka, Douglas MD; Warnick …

Purpose To review the natural history of asymptomatic and symptomatic pediatric Chiari I
malformations with and without syringomyelia. Materials and methods We reviewed the …

Background While clinical factors such as age, grade, stage, and histological subtype provide
physicians with information about patient prognosis, genomic data can further improve …

Germline variants have a rich history of being studied in the context of cancer risk. Emerging
studies now suggest that germline variants contribute not only to cancer risk but to tumor …