An H3K9 methylation-dependent protein interaction regulates the non-enzymatic functions of a putative histone demethylase
G Raiymbek, S An, N Khurana, S Gopinath, A Larkin… - Elife, 2020 - elifesciences.org
H3K9 methylation (H3K9me) specifies the establishment and maintenance of
transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone …
transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone …
[PDF][PDF] Uncoupling the distinct functions of HP1 proteins during heterochromatin establishment and maintenance
M Seman, A Levashkevich, A Larkin, F Huang… - Cell reports, 2023 - cell.com
H3K9 methylation (H3K9me) marks transcriptionally silent genomic regions called heterochromatin.
HP1 proteins are required to establish and maintain heterochromatin. HP1 proteins …
HP1 proteins are required to establish and maintain heterochromatin. HP1 proteins …
The establishment of HP1-independent heterochromatin reveals an essential role for HP1 proteins in maintaining epigenetic memory
M Seman, A Levashkevich, A Larkin, F Huang… - bioRxiv, 2023 - biorxiv.org
H3K9 methylation (H3K9me) marks transcriptionally silent genomic regions called
heterochromatin. A conserved class of HP1 proteins are critically required to establish and maintain …
heterochromatin. A conserved class of HP1 proteins are critically required to establish and maintain …
[HTML][HTML] Identification of a novel, tunable interface in the S. pombe HP1 protein, Swi6, that underpins epigenetic inheritance
A Ames, M Seman, A Larkin, G Raiymbek, Z Chen… - Biorxiv, 2023 - ncbi.nlm.nih.gov
HP1 proteins bind dynamically to H3K9 methylation and are essential for establishing and
maintaining transcriptionally silent epigenetic states, known as heterochromatin. HP1 proteins …
maintaining transcriptionally silent epigenetic states, known as heterochromatin. HP1 proteins …
Investigating mitotic inheritance of histone modifications using tethering strategies
A Larkin, A Ames, M Seman, K Ragunathan - … : Methods and Protocols, 2022 - Springer
The covalent and reversible modification of histones enables cells to establish heritable
gene expression patterns without altering their genetic blueprint. Epigenetic mechanisms …
gene expression patterns without altering their genetic blueprint. Epigenetic mechanisms …
Modeling heterochromatin dynamics in S. pombe across diverse timescales
AM Farhat, S Biswas, Z Chen, A Larkin, K Ragunathan… - Biophysical journal, 2023 - cell.com
From bread yeast to human cancer cells, histone regulation underpins the epigenetics of
almost all eukaryotic genes. While it is possible to experimentally isolate the behavior of single …
almost all eukaryotic genes. While it is possible to experimentally isolate the behavior of single …
Abstract 1826 Single-cell analysis of H3K9me-mediated adaptive pathways in response to heterochromatin misregulation in fission yeast
D Morris-Evans, A Larkin, T Vijayakumar… - Journal of Biological …, 2024 - ASBMB
Histones undergo post-translational modifications that dynamically regulate gene expression.
These modifications enable transcriptome reprogramming in response to intracellular, …
These modifications enable transcriptome reprogramming in response to intracellular, …
Mapping the dynamics of epigenetic adaptation during heterochromatin misregulation
A Larkin, C Kunze, M Seman, A Levashkevich… - bioRxiv, 2023 - biorxiv.org
A classical and well-established mechanism that enables cells to adapt to new and adverse
conditions is the acquisition of beneficial genetic mutations. Much less is known about …
conditions is the acquisition of beneficial genetic mutations. Much less is known about …
An auto-inhibitory mechanism regulates the non-enzymatic functions of a histone demethylase
…, S An, N Khurana, S Gopinath, S Biswas, A Larkin… - bioRxiv, 2019 - biorxiv.org
H3K9 methylation (H3K9me) specifies the establishment and maintenance of
transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone …
transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone …
A non‐enzymatic function associated with a putative histone demethylase regulates heterochromatin spreading and inheritance
…, N Khurana, S Gopinath, S Biswas, A Larkin… - The FASEB …, 2019 - Wiley Online Library
Heterochromatin is characterized by histone hypoacetylation and an enrichment of methylation
marks on histones which are associated with epigenetic silencing. In fission yeast, a …
marks on histones which are associated with epigenetic silencing. In fission yeast, a …