Chromosome segregation requires assembly of kinetochores on centromeric chromatin to
mediate interactions with spindle microtubules and control cell-cycle progression. To …

Laser-induced optical breakdown by femtosecond pulses is extraordinarily precise when
the energy is near threshold. Despite numerous applications, the basis for this deterministic …

Kinetochore attachment to spindle microtubule plus-ends is necessary for accurate
chromosome segregation during cell division in all eukaryotes. The centromeric DNA of each …

A remarkable feature of material damage induced by short-pulsed lasers is that the energy
threshold becomes deterministic for sub-picosecond pulses. This effect, coupled with the …

The kinetochore is a macromolecular protein machine [1] that links centromeric chromatin to
the plus ends of one or more microtubules (MTs) and segregates chromosomes during cell …

During mitosis, sister chromatids congress to the spindle equator and are subsequently
segregated via attachment to dynamic kinetochore microtubule (kMT) plus ends. A major …

Point and regional centromeres specify a unique site on each chromosome for kinetochore
assembly. The point centromere in budding yeast is a unique 150-bp DNA sequence, which …

The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to
the state of attachment of the kinetochore to spindle microtubules. SAC signalling is activated …

During mitosis, chromosomes become attached to microtubules that emanate from the two
spindle poles. Thereafter, a chromosome moves along these microtubule "tracks" as it …

Generation of motile force is one of the main functions of the eukaryotic kinetochore during
cell division. In recent years, the KMN network of proteins (Ndc80 complex, Mis12 complex, …