Dynamic change of chromatin conformation in response to hypoxia enhances the expression of GLUT3 (SLC2A3) by cooperative interaction of hypoxia-inducible …
…, T Shimamura, J Suehiro, A Taguchi… - … and cellular biology, 2012 - Taylor & Francis
Hypoxia-inducible factor 1 (HIF1) is a master regulator of adaptive gene expression under
hypoxia. However, a role for HIF1 in the epigenetic regulation remains unknown. Genome-…
hypoxia. However, a role for HIF1 in the epigenetic regulation remains unknown. Genome-…
Transcriptome analysis of K-877 (a novel selective PPARα modulator (SPPARMα))-regulated genes in primary human hepatocytes and the mouse liver
…, Y Matsumura, K Ikeda, A Taguchi… - … of Atherosclerosis and …, 2015 - jstage.jst.go.jp
Aim: Selective PPARα modulators (SPPARMα) are under development for use as next-generation
lipid lowering drugs. In the current study, to predict the pharmacological and …
lipid lowering drugs. In the current study, to predict the pharmacological and …
[HTML][HTML] Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements
…, G Li, HM Poh, I Mimura, M Kobayashi, A Taguchi… - Genome biology, 2014 - Springer
Background Synergistic transcriptional activation by different stimuli has been reported along
with a diverse array of mechanisms, but the full scope of these mechanisms has yet to be …
with a diverse array of mechanisms, but the full scope of these mechanisms has yet to be …
Chd4 choreographs self-antigen expression for central immune tolerance
…, Y Abe, Y Morishita, T Okamura, A Taguchi… - Nature …, 2020 - nature.com
Autoreactive T cells are eliminated in the thymus to prevent autoimmunity by promiscuous
expression of tissue-restricted self-antigens in medullary thymic epithelial cells. This …
expression of tissue-restricted self-antigens in medullary thymic epithelial cells. This …
Eggshell membrane modulates gut microbiota to prevent murine pre‐cachexia through suppression of T helper cell differentiation
…, K Saito, M Haritani, A Taguchi… - Journal of Cachexia …, 2022 - Wiley Online Library
Background Cachexia is a life‐threatening condition observed in several pathologies, such
as cancer or chronic diseases. Interleukin 10 (Il10) gene transfer is known to improve …
as cancer or chronic diseases. Interleukin 10 (Il10) gene transfer is known to improve …
Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells
…, M Yoshida, R Watanabe, T Tanaka, A Taguchi… - The EMBO …, 2020 - embopress.org
Histone H3 lysine‐9 di‐methylation (H3K9me2) and lysine‐27 tri‐methylation (H3K27me3)
are linked to repression of gene expression, but the functions of repressive histone …
are linked to repression of gene expression, but the functions of repressive histone …
[HTML][HTML] Direct Evidence for Pitavastatin Induced Chromatin Structure Change in the KLF4 Gene in Endothelial Cells
Statins exert atheroprotective effects through the induction of specific transcriptional factors
in multiple organs. In endothelial cells, statin-dependent atheroprotective gene up-regulation …
in multiple organs. In endothelial cells, statin-dependent atheroprotective gene up-regulation …
[HTML][HTML] Effects of chronic low-dose radiation on human neural progenitor cells
…, S Amagasa, Y Kanki, T Inoue, K Kaneki, A Taguchi… - Scientific reports, 2016 - nature.com
The effects of chronic low-dose radiation on human health have not been well established.
Recent studies have revealed that neural progenitor cells are present not only in the fetal …
Recent studies have revealed that neural progenitor cells are present not only in the fetal …
[HTML][HTML] Low-dose radiation induces unstable gene expression in developing human iPSC-derived retinal ganglion organoids
…, Y Urade, H Nansai, M Kobayashi, A Taguchi… - Scientific Reports, 2023 - nature.com
The effects of low-dose radiation on undifferentiated cells carry important implications.
However, the effects on developing retinal cells remain unclear. Here, we analyzed the gene …
However, the effects on developing retinal cells remain unclear. Here, we analyzed the gene …
The serological diversity of serum IgG/IgA/IgM against SARS‐CoV‐2 nucleoprotein, spike, and receptor‐binding domain and neutralizing antibodies in patients with …
…, T Tanaka, K Fukui, A Taguchi… - Health Science …, 2022 - Wiley Online Library
Background We compared the temporal changes of immunoglobulin M (IgM), IgG, and IgA
antibodies against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …
antibodies against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …