Fungi are a rich source of natural products with biological activities. In this study, we evaluated
viral effects on secondary metabolism of the rice blast fungus Magnaporthe oryzae using …

Exclusivity in physical spaces and nutrients is a prerequisite for survival of organisms, but a
few species have been able to develop mutually beneficial strategies that allow them to co-…

Surugamides A–E (1–5), cyclic octapeptides with four d-amino acid residues, were isolated
from the broth of marine-derived Streptomyces sp. Their planar structures were determined …

The cathepsin B inhibitor surugamide B (2), along with structurally related derivatives (A
and C–E), has previously been isolated from the marine actinomycete Streptomyces sp. …

Genome mining is a powerful method for finding novel secondary metabolites. In our study
on the biosynthetic gene cluster for the cyclic octapeptides surugamides A–E (inhibitors of …

Peptidic natural products (PNPs) are widely used compounds that include many antibiotics
and a variety of other bioactive peptides. Although recent breakthroughs in PNP discovery …

Fungi are a rich source of secondary metabolites with potent biological activities. Co-culturing
a fungus with another microorganism has drawn much attention as a practical method for …

A new cyclic lipopeptide aciculitin D (1) was isolated from a Poecillastra sp. marine sponge
collected in the deep-sea. The structure of aciculitin D (1) was elucidated by spectroscopic …

Filamentous fungi produce various bioactive compounds that are biosynthesized by sets of
proteins encoded in biosynthesis gene clusters (BGCs). For an unknown reason, many BGCs …

The filamentous fungal pathogen Aspergillus fumigatus is one of the most common causal
agents of invasive fungal infection in humans; the infection is associated with an alarmingly …