Central nervous system (CNS) injury, including stroke, spinal cord injury, and traumatic brain
injury, causes severe neurological symptoms such as sensory and motor deficits. Currently, …

Myelin is required for the function of neuronal axons in the central nervous system, but the
mechanisms that support myelin health are unclear. Although macrophages in the central …

Age-related regeneration failure in the central nervous system can occur as a result of a
decline in remyelination efficacy. The responsiveness of myelin-forming cells to signals for …

Glial cells play crucial roles in brain homeostasis and pathogenesis of central nervous
system (CNS) injuries and diseases. However, the roles of these cells and the molecular …

Genome stability is essential for brain development and function, as de novo mutations
during neuronal development cause psychiatric disorders. However, the contribution of DNA …

Remyelination is a regenerative process that restores the lost neurological function and
partially depends on oligodendrocyte differentiation. Differentiation of oligodendrocytes …

Lysophosphatidic acid (LPA) is a bioactive lipid that activates the G protein-coupled
receptors, LPA 1-6 , which are associated with a wide number of cellular responses including …

DNA repair is crucial for genome stability in the developing cortex, as somatic de novo
mutations cause neurological disorders. However, how DNA repair contributes to neuronal …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the white matter degeneration. Although changes in blood lipids are involved in the …

Edinburgh Research Explorer Page 1 Edinburgh Research Explorer Microglia regulate
myelin growth and integrity in the central nervous system Citation for published version: …