Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has affected more than seven million people worldwide, …

Recent works have shown the importance of reduction/oxidation (redox) regulation in various
biological phenomena. Thioredoxin (TRX) is one of the major components of the thiol …

Exceptional genomic stability is one of the hallmarks of mouse embryonic stem (ES) cells.
However, the genes contributing to this stability remain obscure. We previously identified …

On entry into mitosis, many transcription factors dissociate from chromatin, resulting in global
transcriptional shutdown. During mitosis, some genes are marked to ensure the inheritance …

Studies were performed to test the hypothesis that reactive oxygen species (ROS) and
mitogen-activated protein kinase (MAPK) contribute to the pathogenesis of aldosterone/salt-…

In recent years, the focus of interest on the role of the renin-angiotensin system (RAS) in the
pathophysiology of hypertension and organ injury has changed to a major emphasis on the …

Thioredoxin (TRX) is a pleiotropic cellular factor that has thiol-mediated redox activity and is
important in regulation of cellular processes, including proliferation, apoptosis, and gene …

We found that when a site-specific binding protein interacts with the “handle” region of the
prorenin prosegment, the prorenin molecule undergoes a conformational change to its …

Thioredoxin (TRX) plays important biological roles both in intra- and extracellular compartments,
including in regulation of various intracellular molecules via thiol redox control. We …

Intrarenal angiotensin II (Ang II) is regulated by several complex processes involving formation
from both systemically delivered and intrarenally formed substrate, as well as receptor-…