A light-sensitive, externally powered microchip was surgically implanted subretinally near
the macular region of volunteers blind from hereditary retinal dystrophy. The implant contains …

This study aims at substituting the essential functions of photoreceptors in patients who are
blind owing to untreatable forms of hereditary retinal degenerations. A microelectronic …

A subretinal visual implant (Alpha IMS, Retina Implant AG, Reutlingen, Germany) was
implanted in 29 blind participants with outer retinal degeneration in an international multicenter …

Human organoids recapitulating the cell-type diversity and function of their target organ are
valuable for basic and translational research. We developed light-sensitive human retinal …

Targeting genes to specific neuronal or glial cell types is valuable for both understanding
and repairing brain circuits. Adeno-associated viruses (AAVs) are frequently used for gene …

Purpose.: The perception of 11 persons blinded by hereditary retinal degeneration elicited by
a subretinally implanted 16-electrode array used for light-independent direct stimulation of …

Neuronal circuit asymmetries are important components of brain circuits, but the molecular
pathways leading to their establishment remain unknown. Here we found that the mutation of …

Purpose.: An active microelectronic subretinal implant, developed to replace the photoreceptive
function in hereditary degenerations of the outer retina, has been applied in a pilot and …

Background Replacing the function of visual pathway neurons by electronic implants is a
novel approach presently explored by various groups in basic research and clinical trials. The …

How closely human organoids recapitulate cell-type diversity and cell-type maturation of their
target organs is not well understood. We developed human retinal organoids with multiple …