Intrinsically disordered proteins are crucial elements of chromatin heterogenous
organization. While disorder in the histone tails enables a large variation of inter-nucleosome …

Pentameric ligand-gated ion channels (pLGICs) are crucial mediators of electrochemical
signal transduction in various organisms from bacteria to humans. Lipids play an important role …

γ-Aminobutyric acid type A (GABA A ) receptors are pentameric ligand-gated ion channels
abundant in the central nervous system and are prolific drug targets for treating anxiety, sleep …

Background and Purpose Cannabidiol (CBD) is used clinically as an anticonvulsant. Its precise
mechanism of action has remained unclear. CBD was recently demonstrated to enhance …

Liquid–liquid phase separation underlies the formation of biological condensates. Physically,
such systems are microemulsions that in general have a propensity to fuse and coalesce; …

Recently, both Magnetic Resonance (MR) Imaging (MRI) and Spectroscopy (MRS) have
emerged as promising tools for detection of prostate cancer (CaP). However, due to the …

Singlet fission (SF), an exciton-doubling process observed in certain molecular semiconductors
where two triplet excitons are generated from one singlet exciton, requires correctly …

Water is often found to mediate interactions between a ligand and a protein. It can play a
significant role in orientating the ligand within a binding pocket and contribute to the free energy …

Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking
neurons. Malfunction of this process due to genetic variants in the KCNC1 gene causes …

Natural photosystems use protein scaffolds to control intermolecular interactions that enable
exciton flow, charge generation, and long-range charge separation. In contrast, there is …