Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …

BACKGROUND: Dilated cardiomyopathy (DCM) is a leading cause of heart failure and death.
The etiology of DCM is genetically heterogeneous. OBJECTIVES: We sought to define the …

Late intracardiac lead perforation is defined as migration and perforation of an implanted
lead after 1 month of cardiac electronic device implantation. It is an under‐recognized …

Background Left ventricular ejection fraction (LVEF) response to guideline-directed medical
therapy (GDMT) and to early cardiac resynchronization therapy (CRT) in new-onset …

SCN5A encodes the voltage-gated Na + channel Na V 1.5 that is responsible for depolarization
of the cardiac action potential and rapid intercellular conduction. Mutations disrupting …

Sudden cardiac death (SCD) is a leading cause of mortality in patients with cardiomyopathy.
Although angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor …

Background The optimal timing for cardiac resynchronization therapy (CRT) after diagnosis
of new‐onset left bundle branch block (LBBB)‐associated idiopathic nonischemic …

Background Non‐vitamin K oral anticoagulants (NOACs) have emerged as alternatives to
vitamin K antagonists in select situations. For left atrial (LA) appendage thrombus in …

Aims The HERMES (HEart failure Molecular Epidemiology for Therapeutic targetS) consortium
aims to identify the genomic and molecular basis of heart failure. Methods and results …

Background We conducted a prospective multicenter study to assess the prognostic value
of combined baseline preimplant plasma levels of the biomarkers cardiac troponin T (TnT) …