User profiles for Aladdin H Shadyab

Aladdin H. Shadyab, PhD

Associate Professor, University of California San Diego
Verified email at ucsd.edu
Cited by 4419

Efficacy of vitamin D3 supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials

…, JAE Manson, RE Neale, R Scragg, AH Shadyab… - Ageing research …, 2023 - Elsevier
To evaluate the effect of vitamin D 3 supplementation on cancer mortality in the general
population and on prognosis in cancer patients, a systematic review and meta-analysis of …

Genetic factors associated with longevity: a review of recent findings

AH Shadyab, AZ LaCroix - Ageing research reviews, 2015 - Elsevier
Given the rising rate of survival into advanced old age in the United States, achieving
longevity and healthy aging is becoming increasingly important. Besides maintaining healthy …

Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

…, D Jain, Z Zheng, LA Cupples, AH Shadyab… - Nature …, 2022 - nature.com
Analyses of data from genome-wide association studies on unrelated individuals have shown
that, for human traits and diseases, approximately one-third to two-thirds of heritability is …

[HTML][HTML] Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

…, U Risérus, JG Robinson, AH Shadyab… - Nature …, 2021 - nature.com
The health effects of omega-3 fatty acids have been controversial. Here we report the
results of a de novo pooled analysis conducted with data from 17 prospective cohort studies …

Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index

…, MA Allison, AH Shadyab… - European heart …, 2019 - academic.oup.com
Aims Central adiposity is associated with increased cardiovascular disease (CVD) risk, even
among people with normal body mass index (BMI). We tested the hypothesis that regional …

Association of normal-weight central obesity with all-cause and cause-specific mortality among postmenopausal women

…, TE Rohan, ML Neuhouser, AH Shadyab… - JAMA network …, 2019 - jamanetwork.com
Importance Current public health guidelines for obesity prevention and control focus on
promoting a normal body mass index (BMI), rarely addressing central obesity, which is reflected …

[HTML][HTML] Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

…, SS Rich, JI Rotter, DA Schwartz, AH Shadyab… - Nature …, 2023 - nature.com
Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and
lack diversity. To overcome this limitation, we aggregated genome-wide association study (…

Association of adverse pregnancy outcomes with risk of atherosclerotic cardiovascular disease in postmenopausal women

…, M Sattari, S Sealy-Jefferson, AH Shadyab… - JAMA …, 2020 - jamanetwork.com
Importance Atherosclerotic cardiovascular disease (ASCVD) may have unique risk factors in
women. Most women have a history of pregnancy; common adverse pregnancy outcomes (…

Sugar-sweetened and artificially sweetened beverages and risk of liver cancer and chronic liver disease mortality

…, M Lopez-Pentecost, N Saquib, AH Shadyab… - Jama, 2023 - jamanetwork.com
Importance Approximately 65% of adults in the US consume sugar-sweetened beverages
daily. Objective To study the associations between intake of sugar-sweetened beverages, …

Generalizing polygenic risk scores from Europeans to Hispanics/Latinos

…, Q Qi, TA Thornton, S Liu, AH Shadyab… - Genetic …, 2019 - Wiley Online Library
Polygenic risk scores (PRSs) are weighted sums of risk allele counts of single‐nucleotide
polymorphisms (SNPs) associated with a disease or trait. PRSs are typically constructed …