Fibronectin (FN) is a dimeric glycoprotein found in the extracellular matrix of most tissues
that serves as a bridge between cells and the interstitial collagen meshwork and influences …

Objectives: The KCNQ1 gene encodes the KvLQT1 potassium channel, which generates in
the human heart the slow component of the cardiac delayed rectifier current, I Ks . Mutations …

Aims Despite improvements in patient identification and management, heart failure (HF)
remains a major public health burden and an important clinical challenge. A variety of animal …

Na current (INa) was monitored in isolated voltage‐clamped frog nodes of Ranvier in order
to analyse the pharmacological and kinetic properties of fast and slow phases of inactivation. …

The synthesis and pharmacological activity of new potent nonpeptide non-tetrazole
angiotensin II (All) receptor antagonists are described. These compounds are 4-thioimidazole …

Objectives: Fibrosis is a classical feature of cardiac hypertrophy. To date changes within the
basal lamina during normal and pathological cardiac growth have been poorly investigated. …

The insulin-like peptide human relaxin-2 was identified as a hormone that, among other
biological functions, mediates the hemodynamic changes occurring during pregnancy. …

Background The therapeutic potential of relaxin for heart failure and renal disease in clinical
trials is hampered by the short half‐life of serelaxin. Optimization of fatty acid‐acetylated …

During 2007–2008, serious adverse events were reported following iv administration of
certain batches of commercially available heparin in humans. Anaphylactoid reactions with …

Aim Heart failure with preserved ejection fraction (HFpEF) is a major cause of death worldwide
with no approved treatment. Left ventricular hypertrophy (LVH) and diastolic dysfunction …