User profiles for Alain Filloux

Alain Filloux

Professor of Molecular Microbiology, Imperial College London
Verified email at imperial.ac.uk
Cited by 18672

[HTML][HTML] Virulence factors of the human opportunistic pathogen Serratia marcescens identified by in vivo screening

…, I Vallet, GPF Michel, M Uh, J Celli, A Filloux… - The EMBO …, 2003 - embopress.org
The human opportunistic pathogen Serratia marcescens is a bacterium with a broad host
range, and represents a growing problem for public health. Serratia marcescens kills …

The bacterial type VI secretion machine: yet another player for protein transport across membranes

A Filloux, A Hachani, S Bleves - Microbiology, 2008 - microbiologyresearch.org
Several secretion systems have evolved that are widespread among Gram-negative bacteria.
Recently, a new secretion system was recognized, which is named the type VI secretion …

[HTML][HTML] Biofilms and cyclic di-GMP (c-di-GMP) signaling: lessons from Pseudomonas aeruginosa and other bacteria

M Valentini, A Filloux - Journal of Biological Chemistry, 2016 - ASBMB
The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that regulates
many bacterial behaviors and is of key importance for driving the lifestyle switch between …

Protein secretion systems in Pseudomonas aeruginosa: A wealth of pathogenic weapons

…, V Viarre, R Salacha, GPF Michel, A Filloux… - International Journal of …, 2010 - Elsevier
Pathogenic microorganisms have to face hostile environments while colonizing and infecting
their hosts. Unfortunately, they can cope with it and have evolved a number of complex …

Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix

…, BS Tseng, M Scian, A Filloux… - Proceedings of the …, 2015 - National Acad Sciences
Biofilm formation is a complex, ordered process. In the opportunistic pathogen Pseudomonas
aeruginosa, Psl and Pel exopolysaccharides and extracellular DNA (eDNA) serve as …

Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes

…, A Lazdunski, S Lory, A Filloux - Proceedings of the …, 2006 - National Acad Sciences
The opportunistic pathogen Pseudomonas aeruginosa is responsible for a wide range of
acute and chronic infections. The transition to chronic infections is accompanied by …

The chaperone/usher pathways of Pseudomonas aeruginosa: Identification of fimbrial gene clusters (cup) and their involvement in biofilm formation

…, S Lory, A Lazdunski, A Filloux - Proceedings of the …, 2001 - National Acad Sciences
Pseudomonas aeruginosa, an important opportunistic human pathogen, persists in certain
tissues in the form of specialized bacterial communities, referred to as biofilm. The biofilm is …

Direct interaction between sensor kinase proteins mediates acute and chronic disease phenotypes in a bacterial pathogen

…, M Merighi, M Hyodo, I Ventre, A Filloux… - Genes & …, 2009 - genesdev.cshlp.org
The genome of the opportunistic pathogen Pseudomonas aeruginosa encodes over 60 two-component
sensor kinases and uses several (including RetS and GacS) to reciprocally …

A novel two‐component system controls the expression of Pseudomonas aeruginosa fimbrial cup genes

…, BR Kulasekara, A Lazdunski, A Filloux… - Molecular …, 2005 - Wiley Online Library
Biofilm formation by the opportunistic pathogen Pseudomonas aeruginosa requires the
expression of a number of surface adhesive components. The expression of surface organelles …

[HTML][HTML] Involvement of the twin‐arginine translocation system in protein secretion via the type II pathway

…, B Ize, ML Vasil, A Lazdunski, LF Wu, A Filloux - The EMBO …, 2001 - embopress.org
The general secretory pathway (GSP) is a two‐step process for the secretion of proteins by
Gram‐negative bacteria. The translocation across the outer membrane is carried out by the …