Programmed polyploidization occurs in all mammalian species during development and
aging in selected tissues, but the biological properties of polyploid cells remain obscure. …

Cellular senescence suppresses cancer by halting the growth of premalignant cells, yet the
accumulation of senescent cells is thought to drive age-related pathology through a …

Cellular senescence suppresses cancer by irreversibly arresting cell proliferation. Senescent
cells acquire a proinflammatory senescence-associated secretory phenotype. Many …

Organoids derived from the liver have hepatocellular differentiation potential and can be an
unlimited source for hepatocytes for application in in vitro toxicology testing and for …

Progeroid mouse models display phenotypes in multiple organ systems that suggest premature
aging and resemble features of natural aging of both mice and humans. The prospect of …

We developed stromal- and epithelial-specific cre-transgenic mice to directly visualize
epithelial-mesenchymal transition (EMT) during cancer progression in vivo. Using three different …

MicroRNAs (miRs) are a class of single-stranded, non-coding RNAs of about 22 nucleotides
in length 1 , 2 . Increasing evidence implicates miRs in myocardial disease processes 3 , 4 , …

The retinoblastoma (Rb) gene was the first tumour suppressor identified 1 . Inactivation of Rb
in mice results in unscheduled cell proliferation, apoptosis and widespread developmental …

The mammalian E2F family of transcription factors plays a crucial role in the regulation of
cellular proliferation, apoptosis, and differentiation. Consistent with its biological role in a …

Metabolic inflammation in adipose tissue and the liver is frequently observed as a result of
diet-induced obesity in human and rodent studies. Although the adipose tissue and the liver …